Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.48 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.48 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.48 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3930649 | 0.86 | MAPT (0.66) | MAPTSMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL1503985 | 0.85 | NPC1 (0.49) | MAPTSMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL12228592 | 0.84 | AR (0.49) | MAPTHTTSLC2A1IDO1MAOB | |
| SCHEMBL22162905 | 0.84 | HPGD (0.60) | MAPTSMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL29666354 | 0.84 | AR (0.49) | MAPTHTTSLC2A1IDO1MAOB | |
| SCHEMBL4894719 | 0.84 | EPHX1 (0.66) | MAPTSMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL3931721 | 0.84 | HPGD (0.57) | MAPTSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL116096 | 0.84 | EPHX1 (0.66) | MAPTSMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL30623277 | 0.82 | IDO1 (0.65) | MAPTSMN1; SMN2SLC2A1MEN1KMT2A | |
| SCHEMBL17601523 | 0.82 | IDO1 (0.65) | MAPTSMN1; SMN2SLC2A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007726-B1 | BENZAMIDE AND HETEROARENE DERIVATIVES AS CETP INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-03-02 | — | — | EP | disclosed |
| EP-1984002-B1 | TRIALKYLSILYLBENZYLAMINOCARBOXYINDOLES, INDAZOLES AND INDOLINES AND THEIR USE IN TREATING CETP-MEDIATED DISORDERS | HOFFMANN LA ROCHE (CH) | 2010-12-22 | — | — | EP | disclosed |
| US-7674815-B2 | Heteroaryl and benzyl amide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-09 | — | — | US | disclosed |
| US-7572823-B2 | Heteroaryl carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2009-08-11 | — | — | US | disclosed |
| WO-2009007259-A1 | PROCESS FOR THE PREPARATION OF AN INDOLE DERIVATIVE | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-15 | — | — | WO | disclosed |
| WO-2009007259-A1 | PROCESS FOR THE PREPARATION OF AN INDOLE DERIVATIVE | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-15 | — | — | WO | disclosed |
| US-20090012311-A1 | PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES | F. HOFFMAN-LA ROCHE AG (CH) | 2009-01-08 | — | — | US | disclosed |
| US-20090012311-A1 | PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES | F. HOFFMAN-LA ROCHE AG (CH) | 2009-01-08 | — | — | US | disclosed |
| US-20090012311-A1 | PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES | F. HOFFMAN-LA ROCHE AG (CH) | 2009-01-08 | — | — | US | disclosed |
| EP-2011783-A1 | Process for the preparation of an indole derivative | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-07 | — | — | EP | disclosed |
| EP-2007726-A2 | BENZAMIDE AND HETEROARENE DERIVATIVES AS CETP INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-12-31 | — | — | EP | disclosed |
| EP-1984002-A1 | TRIALKYLSILYLBENZYLAMINOCARBOXYINDOLES, INDAZOLES AND INDOLINES AND THEIR USE IN TREATING CETP-MEDIATED DISORDERS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-29 | — | — | EP | disclosed |
| US-7259183-B2 | Indole, indazole and indoline derivatives as CETP inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2007-08-21 | — | — | US | disclosed |
| WO-2007090749-A2 | BENZAMIDE AND HETEROARENE DERIVATIVES AS CETP INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-16 | — | — | WO | disclosed |
| WO-2007090750-A1 | TRIALKYLSILYLBENZYLAMINOCARBOXYINDOLES, INDAZOLES AND INDOLINES AND THEIR USE IN TREATING CETP-MEDIATED DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-16 | — | — | WO | disclosed |
| US-20070185182-A1 | Heteroaryl carboxamide compounds | HOFFMAN-LA ROCHE INC. | 2007-08-09 | — | — | US | disclosed |
| US-20070185113-A1 | Heteroaryl and benzyl amide compounds | HOFFMANN-LA ROCHE INC. | 2007-08-09 | — | — | US | disclosed |
| EP-1776338-A1 | INDOLE, INDAZOLE OR INDOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-04-25 | — | — | EP | disclosed |
| US-20060030613-A1 | Indole, indazole and indoline derivatives as CETP inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 2006-02-09 | — | — | US | disclosed |
| WO-2006013048-A1 | INDOLE, INDAZOLE OR INDOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2006-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060030613-A1 | Indole, indazole and indoline derivatives as CETP inhibitors | CETP, NAT1, MTTP | MAPT 1559/4885SMN1; SMN2 4629/4885NPC1 6/4885 |
| US-20090012311-A1 | PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES | IDO1, IDO2, TPH1 | MAPT 1926/4885SMN1; SMN2 4188/4885NPC1 2444/4885 |
| US-20070185113-A1 | Heteroaryl and benzyl amide compounds | CYP2C19, CYP2C9, CYP3A43 | MAPT 2114/4885SMN1; SMN2 3117/4885NPC1 115/4885 |
| US-20070185182-A1 | Heteroaryl carboxamide compounds | ABCB1, ABCG2, CYP3A43 | MAPT 1528/4885SMN1; SMN2 3878/4885NPC1 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.