Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | REN | P00797 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | GHSR | Q92847 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26510556 | 0.96 | CTSC (0.63) | CTSCCYP2C19ALDH1A1THRBCYP2C9 | |
| Hydrochloric Acid SCHEMBL10520878 | 0.94 | CTSC (0.61) | CTSCCYP2C19ALDH1A1THRBCYP2C9 | |
| Hydrochloric Acid SCHEMBL10520881 | 0.94 | CTSC (0.61) | CTSCCYP2C19ALDH1A1THRBCYP2C9 | |
| Hydrochloric Acid SCHEMBL7271124 | 0.94 | CTSC (0.61) | CTSCCYP2C19ALDH1A1THRBCYP2C9 | |
| SCHEMBL10347024 | 0.94 | CTSC (0.54) | CTSCCYP2C19ALDH1A1THRBCYP2C9 | |
| SCHEMBL10868436 | 0.94 | CTSC (0.54) | CTSCCYP2C19ALDH1A1THRBCYP2C9 | |
| SCHEMBL29413760 | 0.92 | CTSC (0.59) | CTSCCYP2C19ALDH1A1THRBCYP2C9 | |
| SCHEMBL10347323 | 0.91 | CTSC (0.52) | CTSCCYP2C19ALDH1A1THRBCYP2C9 | |
| Hydrochloric Acid SCHEMBL10346997 | 0.90 | CTSC (0.51) | CTSCCYP2C19ALDH1A1THRBCYP2C9 | |
| SCHEMBL30546877 | 0.89 | CTSC (0.63) | CTSCRENGHSRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8829208-B2 | Process for the preparation of darunavir and darunavir intermediates | MAPI PHARMA LTD. (IL) | 2014-09-09 | — | — | US | disclosed |
| US-20120296101-A1 | PROCESS FOR THE PREPARATION OF DARUNAVIR AND DARUNAVIR INTERMEDIATES | MAPI PHARMA LIMITED (IL) | 2012-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120296101-A1 | PROCESS FOR THE PREPARATION OF DARUNAVIR AND DARUNAVIR INTERMEDIATES | CYP3A43, CYP3A4, DHPS | CTSC 332/4885CYP2C19 37/4885ALDH1A1 572/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.