SCHEMBL1397464

SCHEMBL1397464

CN1CCN(c2ccc(C(N)=O)cc2)CC1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHEK1 O14757 3/20 0.69
NPC1 O15118 4/20 0.63
RAB9A P51151 4/20 0.63
LMNA P02545 1/20 0.63
TP53 P04637 1/20 0.63
SMN1; SMN2 Q16637 1/20 0.63
ALDH1A1 P00352 3/20 0.59
KDM4E B2RXH2 2/20 0.59
HSD17B10 Q99714 1/20 0.59
GAA P10253 1/20 0.58
MAPT P10636 1/20 0.58
ADRA2C P18825 1/20 0.58
GFER P55789 1/20 0.58
KMT2A Q03164 1/20 0.58
PTK2B Q14289 1/20 0.58
ESR2 Q92731 1/20 0.58
CHRNA7 P36544 1/20 0.58
CHRNA10 Q9GZZ6 1/20 0.58
CHRNA9 Q9UGM1 1/20 0.58
HDAC3 O15379 6/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27778842 0.98 CHEK1 (0.68) CHEK1NPC1RAB9ALMNATP53
Hydrochloric Acid SCHEMBL16210478 0.98 CHEK1 (0.68) CHEK1NPC1RAB9ALMNATP53
SCHEMBL3822792 0.93 CHEK1 (0.63) CHEK1NPC1RAB9ALMNATP53
SCHEMBL19771379 0.85 NPC1 (0.83) CHEK1NPC1RAB9ALMNATP53
SCHEMBL63450 0.83 CHEK1 (0.70) CHEK1NPC1RAB9ALMNATP53
SCHEMBL336009 0.83 NPC1 (0.65) CHEK1NPC1RAB9ALMNATP53
SCHEMBL3883363 0.82 MAPT (0.61) CHEK1NPC1RAB9ALMNATP53
SCHEMBL4985313 0.82 GFER (0.70) CHEK1NPC1RAB9ATP53ALDH1A1
SCHEMBL3128886 0.82 CHRNA7 (0.58) CHEK1ALDH1A1KDM4EGAAKMT2A
SCHEMBL8222647 0.81 ALDH1A1 (0.58) CHEK1NPC1RAB9ALMNATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 137 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115974766-B N-benzyl-3-phenylamide derivative, pharmaceutical composition containing same and application thereof 中国药科大学 2025-05-16 CN claimed
CN-115974766-A N-benzyl-3-phenylamide derivatives, pharmaceutical compositions containing same and uses thereof 中国药科大学 2023-04-18 CN claimed
EP-4135679-A1 MOLECULES FOR USE IN THE TREATMENT OF VIRAL INFECTIONS Istituto Europeo di Oncologia S.r.l. (IT) 2023-02-22 EP claimed
EP-2282995-B1 DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS NOVARTIS AG (CH) 2015-08-26 EP claimed
US-8536175-B2 Quinoxaline carboxamide derivatives as protein tyrosine kinase inhibitors NOVARTIS AG (CH) 2013-09-17 US claimed
EP-2582705-A1 ANELLATED PYRIDINE COMPOUNDS AS DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS F.HOFFMANN-LA ROCHE AG (CH) 2013-04-24 EP claimed
WO-2011161009-A1 ANELLATED PYRIDINE COMPOUNDS AS DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS F. HOFFMANN-LA ROCHE AG (CH) 2011-12-29 WO claimed
CN-102238950-A Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use CHDI INC (US) 2011-11-09 CN claimed
EP-2190834-B1 PYRIDONEAMIDE DERIVATIVES AS FOCAL ADHESION KINASE (FAK) INHIBITORS AND THEIR USE FOR THE TREATMENT OF CANCER HOFFMANN LA ROCHE (CH) 2011-03-02 EP claimed
EP-2190834-A1 PYRIDONEAMIDE DERIVATIVES AS FOCAL ADHESION KINASE (FAK) INHIBITORS AND THEIR USE FOR THE TREATMENT OF CANCER F. Hoffmann-Roche AG (CH) 2010-06-02 EP claimed
WO-2008074749-A9 INDAZOLE DERIVATIVES AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER NERVIANO MEDICAL SCIENCES SRL (IT) 2009-05-07 WO claimed
WO-2009024332-A1 PYRIDONEAMIDE DERIVATIVES AS FOCAL ADHESION KINASE (FAK) INHIBITORS AND THEIR USE FOR THE TREATMENT OF CANCER F. HOFFMANN-LA ROCHE AG (CH) 2009-02-26 WO claimed
WO-2009013126-A1 SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2009-01-29 WO claimed
EP-1901747-A2 PYRIMIDINE-BASED CDK INHIBITORS FOR TREATING PAIN Ingenium Pharmaceuticals AG (DE) 2008-03-26 EP claimed
WO-2007097697-A1 THERAPEUTIC QUINOLINE COMPOUNDS THAT ARE 5HT1B MODULATORS ASTRAZENECA AB (SE) 2007-08-30 WO claimed
WO-2006125616-A2 PYRIMIDINE-BASED CDK INHIBITORS FOR TREATING PAIN INGENIUM PHARMACEUTICALS AG (DE) 2006-11-30 WO claimed
EP-1546150-A1 BIOLOGICALLY ACTIVE COMPOUNDS Amura Therapeutics Limited (GB) 2005-06-29 EP claimed
WO-2004007501-A1 BIOLOGICALLY ACTIVE COMPOUNDS AMURA THERAPEUTICS LIMITED (GB) 2004-01-22 WO claimed
WO-2003047575-A1 THERAPEUTIC BENZAMIDE DERIVATIVES GLAXO GROUP LIMITED (GB) 2003-06-12 WO claimed
WO-2003048121-A1 THERAPEUTIC BENZAMIDE DERIVATIVES GLAXO GROUP LIMITED (GB) 2003-06-12 WO claimed