Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 6/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 6/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4206586 | 0.96 | ADRA2A (0.47) | CCR1ADRA2AADRA2BADRA2CHTR2A | |
| SCHEMBL13977967 | 0.82 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CHTR2AHTR2C | |
| SCHEMBL14911823 | 0.81 | ADRA2A (0.45) | ADRA2AADRA2BADRA2CHTR2AHTR2C | |
| SCHEMBL18183672 | 0.80 | ADRA2A (0.40) | ADRA2AADRA2BADRA2CHTR2AHTR2C | |
| SCHEMBL15961568 | 0.80 | ADRA2A (0.40) | ADRA2AADRA2BADRA2CHTR2AHTR2C | |
| Ammonia Solution, Strong SCHEMBL7996099 | 0.78 | ADRA2A (0.39) | ADRA2AADRA2BADRA2CHTR2AHTR2C | |
| SCHEMBL23425843 | 0.78 | ADRA2A (0.44) | ADRA2AADRA2BADRA2CHTR2AHTR2C | |
| SCHEMBL7002097 | 0.77 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CHTR2AHTR2C | |
| SCHEMBL5335231 | 0.76 | CCR1 (0.43) | CCR1ADRA2AADRA2BADRA2CHTR2A | |
| SCHEMBL11519907 | 0.76 | ADRA2A (0.43) | ADRA2AADRA2BADRA2CHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110062757-B | Factor XIa inhibitors and uses thereof | 广东东阳光药业有限公司 | 2022-03-04 | — | — | CN | disclosed |
| WO-2018133793-A1 | BLOOD COAGULATION FACTOR XIA INHIBITOR AND USES THEREOF | 广东东阳光药业有限公司 | 2018-07-26 | — | — | WO | disclosed |
| WO-2016171181-A1 | 2-SUBSTITUTED FUSED PYRAZOLE DERIVATIVES | 大日本住友製薬株式会社 | 2016-10-27 | — | — | WO | disclosed |
| US-20140235548-A1 | COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION | CLEAVE BIOSCIENCES, INC. (US) | 2014-08-21 | — | — | US | disclosed |
| US-20140235548-A1 | COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION | CLEAVE BIOSCIENCES, INC. (US) | 2014-08-21 | — | — | US | disclosed |
| WO-2012158435-A1 | COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION | ZHOU HAN-JIE (US) | 2012-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140235548-A1 | COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION | USP24, USP36, USP39 | CCR1 4513/4885ADRA2A 4302/4885ADRA2B 3739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.