Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 12/20 | 0.52 |
| ▸ | IKZF3 | Q9UKT9 | 11/20 | 0.52 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 5/20 | 0.40 |
| ▸ | IL1B | P01584 | 3/20 | 0.40 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1398045 | 0.87 | CRBN (0.45) | CRBNIKZF3BRD4CREBBPHTT | |
| SCHEMBL1398091 | 0.84 | TIPARP (0.38) | CRBNIKZF3TNFDDB1 | |
| SCHEMBL1398064 | 0.84 | NPC1 (0.38) | CRBNIKZF3DDB1 | |
| SCHEMBL1398056 | 0.84 | CREBBP (0.37) | CRBNIKZF3CREBBPDDB1 | |
| SCHEMBL1398130 | 0.81 | TP53 (0.39) | CRBNIKZF3BRD4CREBBPDDB1 | |
| SCHEMBL1398096 | 0.80 | CRBN (0.56) | CRBNIKZF3BRD4CREBBPTNF | |
| SCHEMBL1398053 | 0.78 | PDE3B (0.55) | CREBBP | |
| SCHEMBL1398032 | 0.78 | CRBN (0.44) | CRBNIKZF3BRD4TNFIL1B | |
| SCHEMBL1398075 | 0.78 | LMNA (0.44) | CRBNIKZF3BRD4HTTTNF | |
| SCHEMBL1398048 | 0.78 | CRBN (0.39) | CRBNIKZF3BRD4CREBBPDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957481-B1 | PYRROLIDIN(THI)ONES HETEROCYCLICALLY SUBSTITUTED IN 3-POSITION | GRUENENTHAL GMBH (DE) | 2011-03-02 | — | — | EP | claimed |
| US-20080293749-A1 | Pyrrolidine(thi)ones Substituted by Heterocyclic Substituents in The 3-Position | GRUENENTHAL GMBH (DE) | 2008-11-27 | — | — | US | claimed |
| EP-1957481-B1 | PYRROLIDIN(THI)ONES HETEROCYCLICALLY SUBSTITUTED IN 3-POSITION | GRUENENTHAL GMBH (DE) | 2011-03-02 | — | — | EP | disclosed |
| US-20080293749-A1 | Pyrrolidine(thi)ones Substituted by Heterocyclic Substituents in The 3-Position | GRUENENTHAL GMBH (DE) | 2008-11-27 | — | — | US | disclosed |
| EP-1957481-A1 | PYRROLIDIN(THI)ONES HETEROCYCLICALLY SUBSTITUTED IN 3-POSITION | Grünenthal GmbH (DE) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007062817-A1 | PYRROLIDIN(THI)ONES HETEROCYCLICALLY SUBSTITUTED IN 3-POSITION | Grünenthal GmbH (DE) | 2007-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293749-A1 | Pyrrolidine(thi)ones Substituted by Heterocyclic Substituents in The 3-Position | TPMT, MALT1, THPO | CRBN 1317/4885IKZF3 78/4885BRD4 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.