Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.47 |
| ▸ | HTR1D | P28221 | 10/20 | 0.47 |
| ▸ | HTR1B | P28222 | 9/20 | 0.47 |
| ▸ | DRD2 | P14416 | 6/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.47 |
| ▸ | HTR7 | P34969 | 4/20 | 0.47 |
| ▸ | DRD3 | P35462 | 4/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | HTR2C | P28335 | 3/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13982037 | 0.82 | HTR1A (0.47) | HTR1AHTR1DHTR1BDRD2ADRB1 | |
| SCHEMBL13927953 | 0.80 | HTR1A (0.46) | HTR1AHTR1DHTR1BDRD2ADRB1 | |
| SCHEMBL4178800 | 0.80 | HTR1A (0.47) | HTR1AHTR1DHTR1BDRD2ADRB1 | |
| SCHEMBL13950983 | 0.79 | HTR1A (0.50) | HTR1AHTR1DHTR1BDRD2ADRB1 | |
| SCHEMBL13981927 | 0.79 | PARP1 (0.49) | HTR1AHTR1DHTR1BDRD2ADRB1 | |
| SCHEMBL13927941 | 0.74 | EED (0.46) | HTR1AHTR1DHTR1BDRD2ADRB1 | |
| Hydrochloric Acid SCHEMBL4491277 | 0.74 | EED (0.45) | HTR1AHTR1DHTR1BDRD2ADRB1 | |
| SCHEMBL13981942 | 0.74 | HTR1A (0.46) | HTR1AHTR1DHTR1BDRD2ADRB1 | |
| Hydrochloric Acid SCHEMBL6831458 | 0.73 | HTR1A (0.49) | HTR1AHTR1DHTR1BDRD2ADRB1 | |
| SCHEMBL24775925 | 0.69 | HTR1A (0.43) | HTR1AHTR1DHTR1BDRD2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008150848-A1 | ANTIDEPRESSANT HETEROARYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | WYETH (US) | 2008-12-11 | — | — | WO | disclosed |