Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8930527 | 0.93 | HSP90AA1 (0.59) | TDP1ALDH1A1HTTKDM4EHSP90AA1 | |
| SCHEMBL13983414 | 0.90 | HSP90AA1 (0.62) | TDP1ALDH1A1HTTKDM4EHSP90AA1 | |
| SCHEMBL13983483 | 0.88 | KDM4E (0.48) | TDP1ALDH1A1HTTKDM4EHSP90AA1 | |
| SCHEMBL13983103 | 0.86 | ALDH1A1 (0.48) | TDP1ALDH1A1HTTKDM4EHSP90AA1 | |
| SCHEMBL13983088 | 0.84 | HSP90AA1 (0.53) | TDP1ALDH1A1HTTKDM4EHSP90AA1 | |
| SCHEMBL13983420 | 0.84 | HSP90AA1 (0.64) | TDP1ALDH1A1HTTKDM4EHSP90AA1 | |
| SCHEMBL13983479 | 0.84 | HSP90AA1 (0.60) | TDP1ALDH1A1HTTKDM4EHSP90AA1 | |
| SCHEMBL10344967 | 0.83 | KDM4E (0.44) | TDP1ALDH1A1HTTKDM4EHSP90AA1 | |
| SCHEMBL13983080 | 0.83 | HSP90AA1 (0.64) | TDP1ALDH1A1HTTKDM4EHSP90AA1 | |
| SCHEMBL8930932 | 0.82 | HSP90AA1 (0.73) | TDP1ALDH1A1HTTKDM4EHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008153730-A2 | METHOD FOR TREATING PROLIFERATIVE DISORDERS ASSOCIATED WITH MUTATIONS IN C-MET | SYNTA PHARMACEUTICALS CORP. (US) | 2008-12-18 | — | — | WO | disclosed |
| WO-2007140002-A2 | METHOD FOR TREATING NON-HODGKIN'S LYMPHOMA | SYNTA PHARMACEUTICALS CORP. (US) | 2007-12-06 | — | — | WO | disclosed |