Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.56 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.50 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.50 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13267169 | 1.00 | HIF1A (0.56) | HIF1AEPAS1ALDH1A1HDAC1KMT2A | |
| SCHEMBL13244790 | 0.91 | HIF1A (0.53) | HIF1AEPAS1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL15382489 | 0.91 | HIF1A (0.53) | HIF1AEPAS1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL13984818 | 0.87 | HIF1A (0.57) | HIF1AEPAS1ALDH1A1HDAC1SMN1; SMN2 | |
| SCHEMBL13267167 | 0.87 | HIF1A (0.57) | HIF1AEPAS1ALDH1A1HDAC1SMN1; SMN2 | |
| SCHEMBL1109094 | 0.81 | KMT2A (0.59) | HIF1AEPAS1HDAC1KMT2ASMN1; SMN2 | |
| SCHEMBL13267242 | 0.81 | KMT2A (0.56) | HIF1AEPAS1HDAC1KMT2ASMN1; SMN2 | |
| SCHEMBL14400805 | 0.81 | KMT2A (0.59) | HIF1AEPAS1HDAC1KMT2ASMN1; SMN2 | |
| SCHEMBL13266877 | 0.80 | SMN1; SMN2 (0.56) | HIF1AEPAS1KMT2ASMN1; SMN2MAPK1 | |
| SCHEMBL13266878 | 0.80 | KMT2A (0.55) | HIF1AEPAS1HDAC1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008154642-A2 | ANTIBACTERIAL AGENTS | ACHAOGEN, INC. (US) | 2008-12-18 | — | — | WO | disclosed |