Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ANPEP | P15144 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.49 |
| ▸ | MTTP | P55157 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13984818 | 1.00 | HIF1A (0.57) | HIF1AEPAS1ALDH1A1HDAC1HDAC4 | |
| SCHEMBL28847817 | 0.92 | HIF1A (0.55) | HIF1AEPAS1ALDH1A1HDAC1HDAC4 | |
| SCHEMBL13267197 | 0.92 | HIF1A (0.55) | HIF1AEPAS1ALDH1A1HDAC1HDAC4 | |
| SCHEMBL3007221 | 0.91 | HIF1A (0.54) | HIF1AEPAS1ALDH1A1 | |
| SCHEMBL3007224 | 0.91 | HIF1A (0.54) | HIF1AEPAS1ALDH1A1 | |
| SCHEMBL13984817 | 0.87 | HIF1A (0.56) | HIF1AEPAS1ALDH1A1HDAC1RAB9A | |
| SCHEMBL13267169 | 0.87 | HIF1A (0.56) | HIF1AEPAS1ALDH1A1HDAC1RAB9A | |
| SCHEMBL13267483 | 0.86 | NPC1 (0.47) | HIF1AEPAS1ALDH1A1HDAC1RAB9A | |
| SCHEMBL13267378 | 0.84 | NPC1 (0.50) | HIF1AEPAS1ALDH1A1HDAC1RAB9A | |
| SCHEMBL13245281 | 0.84 | HIF1A (0.47) | HIF1AEPAS1ALDH1A1HDAC1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190766-A1 | ANTIBACTERIAL AGENTS | ACHAOGEN, INC. (US) | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190766-A1 | ANTIBACTERIAL AGENTS | MRPL21, SI, ABCB11 | HIF1A 2073/4885EPAS1 3545/4885ALDH1A1 687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.