Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.64 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13941569 | 0.83 | EGFR (0.66) | EGFRPIK3CANPC1RAB9ALMNA | |
| SCHEMBL13941369 | 0.83 | EGFR (0.66) | EGFRPIK3CANPC1RAB9ALMNA | |
| SCHEMBL15478841 | 0.79 | EGFR (1.00) | EGFRPIK3CANPC1RAB9ALMNA | |
| SCHEMBL13985114 | 0.77 | MAPT (0.54) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL13941381 | 0.74 | EGFR (0.52) | EGFRPIK3CANPC1RAB9ALMNA | |
| SCHEMBL19476163 | 0.73 | NPC1 (0.78) | EGFRPIK3CANPC1RAB9ALMNA | |
| SCHEMBL13941708 | 0.73 | EGFR (0.52) | EGFRPIK3CANPC1RAB9ALMNA | |
| SCHEMBL8769590 | 0.73 | NPC1 (0.82) | EGFRPIK3CANPC1RAB9ALMNA | |
| SCHEMBL11719988 | 0.73 | EGFR (0.63) | EGFRPIK3CANPC1RAB9ALMNA | |
| SCHEMBL7208136 | 0.73 | NPC1 (1.00) | EGFRPIK3CANPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155675-B1 | KINASE INHIBITORS, COMPOSITIONS THEREOF, AND METHODS OF USE THEREWITH | PROVID PHARMACEUTICALS INC (US) | 2014-02-19 | — | — | EP | disclosed |
| WO-2008156573-A1 | KINASE INHIBITORS, COMPOSITIONS THEREOF, AND METHODS OF USE THEREWITH | PROVID PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |