Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.64 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.64 |
| ▸ | AURKA | O14965 | 1/20 | 0.64 |
| ▸ | CHUK | O15111 | 1/20 | 0.64 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.64 |
| ▸ | JAK2 | O60674 | 1/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.64 |
| ▸ | PAK4 | O96013 | 1/20 | 0.64 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.64 |
| ▸ | CDK1 | P06493 | 1/20 | 0.64 |
| ▸ | PIM1 | P11309 | 1/20 | 0.64 |
| ▸ | PRKACA | P17612 | 1/20 | 0.64 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.64 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.64 |
| ▸ | CDK2 | P24941 | 1/20 | 0.64 |
| ▸ | MARK3 | P27448 | 1/20 | 0.64 |
| ▸ | AKT1 | P31749 | 1/20 | 0.64 |
| ▸ | AKT2 | P31751 | 1/20 | 0.64 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.64 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13431060 | 0.95 | PLK4 (0.70) | PLK4CHEK1AURKACHUKDAPK3 | |
| SCHEMBL15849842 | 0.90 | MAPT (0.56) | PLK4CHEK1AURKACHUKDAPK3 | |
| SCHEMBL13160507 | 0.89 | PLK4 (0.57) | PLK4CHEK1AURKACHUKDAPK3 | |
| SCHEMBL13431057 | 0.89 | PLK4 (0.57) | PLK4CHEK1AURKACHUKDAPK3 | |
| SCHEMBL13941402 | 0.89 | PLK4 (0.57) | PLK4CHEK1AURKACHUKDAPK3 | |
| SCHEMBL16275220 | 0.89 | PLK4 (0.55) | PLK4CHEK1AURKACHUKDAPK3 | |
| SCHEMBL15849839 | 0.88 | PLK4 (0.68) | PLK4CHEK1AURKACHUKDAPK3 | |
| SCHEMBL13941399 | 0.85 | NPC1 (0.54) | PLK4CHEK1AURKACHUKDAPK3 | |
| SCHEMBL13941428 | 0.85 | FAAH (0.54) | PLK4CHEK1AURKACHUKDAPK3 | |
| SCHEMBL13941421 | 0.84 | PLK4 (0.52) | PLK4CHEK1AURKACHUKDAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8765802-B2 | Kinase inhibitors, compositions thereof, and methods of use therewith | PROVID PHARMACEUTICALS, INC. (US) | 2014-07-01 | — | — | US | disclosed |
| WO-2008156573-A1 | KINASE INHIBITORS, COMPOSITIONS THEREOF, AND METHODS OF USE THEREWITH | PROVID PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |