Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13985157 | 0.94 | TP53 (0.48) | TP53KDM4ESMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL13966280 | 0.94 | TP53 (0.48) | TP53KDM4ESMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL13941363 | 0.94 | TP53 (0.48) | TP53KDM4ESMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL13941574 | 0.88 | TP53 (0.43) | TP53KDM4ESMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL13941359 | 0.88 | PLK4 (0.49) | TP53KMT2APLK4CHEK1AURKA | |
| SCHEMBL13941566 | 0.86 | PLK4 (0.47) | TP53KMT2APLK4CHEK1AURKA | |
| SCHEMBL13985294 | 0.84 | MAPT (0.45) | TP53KDM4ESMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL13431059 | 0.83 | TP53 (0.61) | TP53KDM4ESMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL15849841 | 0.80 | PLK4 (0.53) | PLK4CHEK1AURKACHUKDAPK3 | |
| SCHEMBL21882634 | 0.77 | SMN1; SMN2 (0.54) | KDM4ESMN1; SMN2KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8765802-B2 | Kinase inhibitors, compositions thereof, and methods of use therewith | PROVID PHARMACEUTICALS, INC. (US) | 2014-07-01 | — | — | US | disclosed |
| WO-2008156573-A1 | KINASE INHIBITORS, COMPOSITIONS THEREOF, AND METHODS OF USE THEREWITH | PROVID PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |