Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 12/20 | 0.51 |
| ▸ | HCRTR2 | O43614 | 12/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4787256 | 0.95 | HCRTR1 (0.52) | HCRTR1HCRTR2 | |
| SCHEMBL1398732 | 0.92 | HCRTR1 (0.60) | HCRTR1HCRTR2MAPK1 | |
| SCHEMBL1398641 | 0.92 | HCRTR1 (0.60) | HCRTR1HCRTR2MAPK1 | |
| SCHEMBL1398696 | 0.92 | HCRTR1 (0.60) | HCRTR1HCRTR2MAPK1 | |
| SCHEMBL1398814 | 0.87 | HCRTR1 (0.44) | HCRTR1HCRTR2 | |
| SCHEMBL4786488 | 0.86 | HCRTR1 (0.57) | HCRTR1HCRTR2 | |
| SCHEMBL1398777 | 0.86 | HCRTR1 (0.44) | HCRTR1HCRTR2 | |
| SCHEMBL1398842 | 0.86 | HCRTR1 (0.44) | HCRTR1HCRTR2 | |
| SCHEMBL1398634 | 0.86 | HCRTR1 (0.44) | HCRTR1HCRTR2 | |
| SCHEMBL1398667 | 0.86 | HCRTR1 (0.44) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7994336-B2 | Azetidine compounds as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-08-09 | — | — | US | claimed |
| EP-2069332-B1 | AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-03-02 | — | — | EP | claimed |
| US-7994336-B2 | Azetidine compounds as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-08-09 | — | — | US | disclosed |
| EP-2069332-B1 | AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-03-02 | — | — | EP | disclosed |