Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 19/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 16/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1398846 | 1.00 | HCRTR1 (0.44) | HCRTR1HCRTR2CHRM2CHRM4CHRM5 | |
| SCHEMBL1398688 | 1.00 | HCRTR1 (0.44) | HCRTR1HCRTR2CHRM2CHRM4CHRM5 | |
| SCHEMBL1398811 | 0.87 | HCRTR1 (0.44) | HCRTR1HCRTR2CHRM2CHRM4CHRM5 | |
| SCHEMBL1398614 | 0.87 | HCRTR1 (0.44) | HCRTR1HCRTR2CHRM2CHRM4CHRM5 | |
| SCHEMBL1398666 | 0.87 | HCRTR1 (0.44) | HCRTR1HCRTR2CHRM2CHRM4CHRM5 | |
| SCHEMBL1398622 | 0.86 | HCRTR1 (0.44) | HCRTR1HCRTR2CHRM2CHRM4CHRM5 | |
| SCHEMBL1398703 | 0.86 | HCRTR1 (0.44) | HCRTR1HCRTR2CHRM2CHRM4CHRM5 | |
| SCHEMBL1398535 | 0.86 | HCRTR1 (0.51) | HCRTR1HCRTR2 | |
| SCHEMBL1398617 | 0.86 | HCRTR1 (0.44) | HCRTR1HCRTR2CHRM2CHRM4CHRM5 | |
| SCHEMBL1398641 | 0.84 | HCRTR1 (0.60) | HCRTR1HCRTR2CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069332-B1 | AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-03-02 | — | — | EP | claimed |
| US-7994336-B2 | Azetidine compounds as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-08-09 | — | — | US | disclosed |
| EP-2069332-B1 | AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-03-02 | — | — | EP | disclosed |