Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.88 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Brincidofovir SCHEMBL139922 | 0.94 | FGFR1 (1.00) | FGFR1SLC22A6CYP3A4CYP2D6 | |
| Brincidofovir SCHEMBL12918810 | 0.94 | FGFR1 (1.00) | FGFR1SLC22A6CYP3A4CYP2D6 | |
| SCHEMBL22863226 | 0.94 | FGFR1 (1.00) | FGFR1SLC22A6CYP3A4CYP2D6 | |
| SCHEMBL18419059 | 0.92 | FGFR1 (0.75) | FGFR1SLC22A6CYP3A4CYP2D6 | |
| SCHEMBL29708091 | 0.90 | FGFR1 (0.93) | FGFR1SLC22A6CYP3A4CYP2D6 | |
| SCHEMBL14665282 | 0.89 | FGFR1 (0.82) | FGFR1SLC22A6CYP3A4CYP2D6 | |
| SCHEMBL14665327 | 0.89 | FGFR1 (0.82) | FGFR1SLC22A6CYP3A4CYP2D6 | |
| SCHEMBL14665389 | 0.89 | FGFR1 (0.82) | FGFR1SLC22A6CYP3A4CYP2D6 | |
| SCHEMBL16518411 | 0.86 | FGFR1 (0.86) | FGFR1SLC22A6CYP3A4CYP2D6 | |
| SCHEMBL10081920 | 0.86 | FGFR1 (0.84) | FGFR1SLC22A6CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11912667-B2 | Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof | EMERGENT BIODEFENSE OPERATIONS LANSING LLC (US) | 2024-02-27 | — | — | US | disclosed |
| US-20180086721-A1 | MORPHIC FORMS OF HEXADECYLOXYPROPYL-PHOSPHONATE ESTERS AND METHODS OF SYNTHESIS THEREOF | EMERGENT BIODEFENSE OPERATIONS LANSING LLC | 2018-03-29 | — | — | US | disclosed |
| US-9862687-B2 | Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof | CHIMERIX, INC. (US) | 2018-01-09 | — | — | US | disclosed |
| US-20160264531-A1 | MORPHIC FORMS OF HEXADECYLOXYPROPYL-PHOSPHONATE ESTERS AND METHODS OF SYNTHESIS THEREOF | EMERGENT BIODEFENSE OPERATIONS LANSING LLC | 2016-09-15 | — | — | US | disclosed |
| US-9371344-B2 | Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof | CHIMERIX, INC. (US) | 2016-06-21 | — | — | US | disclosed |
| US-9303051-B2 | Phosphonate ester derivatives and methods of synthesis thereof | CHIMERIX INC. (US) | 2016-04-05 | — | — | US | disclosed |
| US-20150329575-A1 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF | EMERGENT BIODEFENSE OPERATIONS LANSING LLC | 2015-11-19 | — | — | US | disclosed |
| US-20150210724-A1 | MORPHIC FORMS OF HEXADECYLOXYPROPYL-PHOSPHONATE ESTERS AND METHODS OF SYNTHESIS THEREOF | EMERGENT BIODEFENSE OPERATIONS LANSING LLC | 2015-07-30 | — | — | US | disclosed |
| US-8962829-B1 | Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof | CHIMERIX, INC. (US) | 2015-02-24 | — | — | US | disclosed |
| US-20140046085-A1 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof | CHIMERIX, INC. (US) | 2014-02-13 | — | — | US | disclosed |
| US-8569321-B2 | Phosphonate ester derivatives and methods of synthesis thereof | CHIMERIX, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-20120058976-A1 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof | CHIMERIX, INC. (US) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11912667-B2 | Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof | PHOSPHO1, PPIP5K2, FASN | FGFR1 2788/4885SLC22A6 2615/4885CYP3A4 1005/4885 |
| US-20180086721-A1 | MORPHIC FORMS OF HEXADECYLOXYPROPYL-PHOSPHONATE ESTERS AND METHODS OF SYNTHESIS THEREOF | PHOSPHO1, PPIP5K2, FASN | FGFR1 2788/4885SLC22A6 2615/4885CYP3A4 1005/4885 |
| US-20120058976-A1 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof | PHOSPHO1, PIK3CA, PNP | FGFR1 2756/4885SLC22A6 3161/4885CYP3A4 990/4885 |
| US-20140046085-A1 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof | PHOSPHO1, PIK3CA, PNP | FGFR1 2756/4885SLC22A6 3161/4885CYP3A4 990/4885 |
| US-20150329575-A1 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF | PHOSPHO1, PIK3CA, PNP | FGFR1 2756/4885SLC22A6 3161/4885CYP3A4 990/4885 |
| US-20150210724-A1 | MORPHIC FORMS OF HEXADECYLOXYPROPYL-PHOSPHONATE ESTERS AND METHODS OF SYNTHESIS THEREOF | PHOSPHO1, PPIP5K2, FASN | FGFR1 2788/4885SLC22A6 2615/4885CYP3A4 1005/4885 |
| US-20160264531-A1 | MORPHIC FORMS OF HEXADECYLOXYPROPYL-PHOSPHONATE ESTERS AND METHODS OF SYNTHESIS THEREOF | PHOSPHO1, PPIP5K2, FASN | FGFR1 2788/4885SLC22A6 2615/4885CYP3A4 1005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.