Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14348306 | 1.00 | KDM4E (0.55) | KDM4EALDH1A1L3MBTL1POLBTSHR | |
| SCHEMBL5232137 | 0.84 | GSK3B (0.59) | GSK3B | |
| SCHEMBL5235149 | 0.83 | GSK3B (0.56) | POLBGSK3BRAB9AKMT2AMEN1 | |
| SCHEMBL13987012 | 0.80 | GSK3B (0.55) | ALDH1A1L3MBTL1GSK3BRXFP1MAPT | |
| SCHEMBL17883287 | 0.78 | ALDH1A1 (0.62) | KDM4EALDH1A1L3MBTL1POLBRXFP1 | |
| SCHEMBL13987018 | 0.76 | GSK3B (0.53) | ALDH1A1L3MBTL1GSK3BMAPTKMT2A | |
| SCHEMBL5236116 | 0.76 | GSK3B (0.52) | ALDH1A1L3MBTL1GSK3BKMT2AMEN1 | |
| SCHEMBL5233639 | 0.76 | GSK3B (0.52) | ALDH1A1GSK3BKMT2AMEN1GAA | |
| SCHEMBL4856282 | 0.76 | GSK3B (0.69) | POLBTSHRGSK3BGAASMN1; SMN2 | |
| SCHEMBL5232508 | 0.76 | MAPK8 (0.55) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |