Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | PHGDH | O43175 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13986977 | 0.90 | ALDH1A1 (0.52) | ALDH1A1MAPTGSK3BMAPK1ROCK2 | |
| SCHEMBL13986956 | 0.90 | GSK3B (0.48) | ALDH1A1MAPTGSK3BMAPK1ROCK2 | |
| SCHEMBL13986933 | 0.90 | ALDH1A1 (0.52) | ALDH1A1MAPTGSK3BMAPK1ROCK2 | |
| SCHEMBL13986931 | 0.90 | ALDH1A1 (0.52) | ALDH1A1MAPTGSK3BMAPK1ROCK2 | |
| SCHEMBL13986985 | 0.90 | GSK3B (0.58) | ALDH1A1MAPTGSK3BMAPK1ROCK2 | |
| SCHEMBL13986994 | 0.90 | MAPK1 (0.56) | ALDH1A1MAPTGSK3BPHGDHMAPK1 | |
| SCHEMBL13987009 | 0.88 | GSK3B (0.54) | ALDH1A1MAPTGSK3BPHGDHMAPK1 | |
| SCHEMBL13986995 | 0.85 | PDE2A (0.49) | ALDH1A1MAPTGSK3BMAPK1ROCK2 | |
| SCHEMBL13986991 | 0.81 | ROCK1 (0.63) | GSK3BMAPK1ROCK2RPS6KA5MAP4K4 | |
| SCHEMBL13986999 | 0.81 | GSK3B (0.47) | ALDH1A1MAPTGSK3BROCK2GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |