Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 16/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 13/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1398622 | 1.00 | HCRTR1 (0.44) | HCRTR1HCRTR2IDO1KDM4EALDH1A1 | |
| SCHEMBL1398617 | 1.00 | HCRTR1 (0.44) | HCRTR1HCRTR2IDO1KDM4EALDH1A1 | |
| SCHEMBL1398902 | 0.87 | HCRTR1 (0.44) | HCRTR1HCRTR2CHRM2CHRM4CHRM5 | |
| SCHEMBL1398876 | 0.86 | HCRTR1 (0.44) | HCRTR1HCRTR2CHRM2CHRM4CHRM5 | |
| SCHEMBL1398634 | 0.86 | HCRTR1 (0.44) | HCRTR1HCRTR2CHRM2CHRM4CHRM5 | |
| SCHEMBL1398777 | 0.86 | HCRTR1 (0.44) | HCRTR1HCRTR2CHRM2CHRM4CHRM5 | |
| SCHEMBL1398665 | 0.86 | HCRTR1 (0.44) | HCRTR1HCRTR2CHRM2CHRM4CHRM5 | |
| SCHEMBL1398842 | 0.86 | HCRTR1 (0.44) | HCRTR1HCRTR2CHRM2CHRM4CHRM5 | |
| SCHEMBL1398688 | 0.86 | HCRTR1 (0.44) | HCRTR1HCRTR2CHRM2CHRM4CHRM5 | |
| SCHEMBL1398667 | 0.86 | HCRTR1 (0.44) | HCRTR1HCRTR2CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7994336-B2 | Azetidine compounds as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-08-09 | — | — | US | disclosed |
| EP-2069332-B1 | AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-03-02 | — | — | EP | disclosed |