Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 13/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13015199 | 0.85 | CALCRL (0.33) | CALCRLCYP3A4 | |
| SCHEMBL3662633 | 0.82 | CALCRL (0.41) | CALCRLCYP3A4 | |
| SCHEMBL3783469 | 0.82 | CALCRL (0.34) | CALCRLCYP3A4 | |
| SCHEMBL13987068 | 0.77 | CALCRL (0.39) | CALCRLCYP3A4 | |
| SCHEMBL3627780 | 0.74 | CALCRL (0.39) | CALCRLCYP3A4 | |
| SCHEMBL2213255 | 0.72 | CALCRL (0.55) | CALCRLCYP3A4 | |
| SCHEMBL2213262 | 0.72 | CALCRL (0.55) | CALCRLCYP3A4 | |
| SCHEMBL13987076 | 0.64 | CALCRL (0.54) | CALCRLCYP3A4 | |
| SCHEMBL3896405 | 0.63 | CALCRL (0.53) | CALCRLCYP3A4 | |
| SCHEMBL2215067 | 0.63 | CALCRL (0.53) | CALCRLCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470679-B2 | Constrained compounds as CGRP-receptor antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-12-30 | — | — | US | disclosed |
| US-20070259850-A1 | CONSTRAINED COMPOUNDS AS CGRP-RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259850-A1 | CONSTRAINED COMPOUNDS AS CGRP-RECEPTOR ANTAGONISTS | CALCR, BDKRB2, CALCRL | CALCRL 3/4885CYP3A4 3221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.