Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 17/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 13/20 | 0.49 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1398801 | 1.00 | HCRTR1 (0.49) | HCRTR1HCRTR2MRGPRX1 | |
| SCHEMBL1398687 | 1.00 | HCRTR1 (0.49) | HCRTR1HCRTR2MRGPRX1 | |
| SCHEMBL20827737 | 0.94 | HCRTR1 (0.55) | HCRTR1HCRTR2 | |
| SCHEMBL1398584 | 0.87 | HCRTR1 (0.47) | HCRTR1HCRTR2MRGPRX1 | |
| SCHEMBL1398546 | 0.85 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL1398554 | 0.83 | HCRTR1 (0.43) | HCRTR1HCRTR2MRGPRX1 | |
| SCHEMBL1398628 | 0.81 | HCRTR1 (0.60) | HCRTR1HCRTR2 | |
| SCHEMBL1398698 | 0.81 | HCRTR1 (0.60) | HCRTR1HCRTR2 | |
| SCHEMBL1398579 | 0.81 | HCRTR1 (0.60) | HCRTR1HCRTR2 | |
| SCHEMBL1398954 | 0.75 | HCRTR1 (0.57) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7994336-B2 | Azetidine compounds as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-08-09 | — | — | US | disclosed |
| EP-2069332-B1 | AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-03-02 | — | — | EP | disclosed |