Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 11/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.37 |
| ▸ | HCN1 | O60741 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1398546 | 0.89 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL1398584 | 0.84 | HCRTR1 (0.47) | HCRTR1HCRTR2MRGPRX1 | |
| SCHEMBL1398801 | 0.83 | HCRTR1 (0.49) | HCRTR1HCRTR2MRGPRX1 | |
| SCHEMBL1398708 | 0.83 | HCRTR1 (0.49) | HCRTR1HCRTR2MRGPRX1 | |
| SCHEMBL1398687 | 0.83 | HCRTR1 (0.49) | HCRTR1HCRTR2MRGPRX1 | |
| SCHEMBL1398678 | 0.73 | HCRTR1 (0.55) | HCRTR1HCRTR2 | |
| SCHEMBL1398772 | 0.72 | HCRTR1 (0.51) | HCRTR1HCRTR2CACNA1H | |
| SCHEMBL1398874 | 0.71 | RORC (0.49) | RORCOPRM1MMP2MMP13 | |
| SCHEMBL1398589 | 0.69 | HCRTR1 (0.49) | HCRTR1HCRTR2 | |
| SCHEMBL1398722 | 0.69 | HCRTR1 (0.61) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7994336-B2 | Azetidine compounds as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-08-09 | — | — | US | claimed |
| EP-2069332-B1 | AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-03-02 | — | — | EP | claimed |
| US-7994336-B2 | Azetidine compounds as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-08-09 | — | — | US | disclosed |
| EP-2069332-B1 | AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-03-02 | — | — | EP | disclosed |