SCHEMBL13987643

SCHEMBL13987643

COc1ccccc1CCNCCCC(=O)c1cc2c3c(c1)CCN3C(=O)CC2

nearest known ligand 0.61

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.49
ACHE P22303 2/20 0.46
CYP11B1 P15538 3/20 0.44
CYP11B2 P19099 2/20 0.44
CYP19A1 P11511 2/20 0.44
TP53 P04637 1/20 0.43
CYP1A2 P05177 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
KCNH2 Q12809 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4862373 0.99 TDP1 (0.49) TDP1ACHECYP11B1CYP11B2CYP19A1
SCHEMBL13987242 0.97 TDP1 (0.49) TDP1ACHECYP11B1CYP11B2CYP19A1
SCHEMBL13987277 0.96 TDP1 (0.48) TDP1ACHECYP11B1CYP11B2CYP19A1
Hydrochloric Acid SCHEMBL4858964 0.96 TDP1 (0.48) TDP1ACHECYP11B1CYP11B2CYP19A1
Hydrochloric Acid SCHEMBL4861561 0.96 TDP1 (0.47) TDP1ACHECYP11B1CYP11B2CYP19A1
SCHEMBL13987324 0.92 ACHE (0.47) TDP1ACHE
SCHEMBL13987338 0.91 ACHE (0.46) TDP1ACHE
Hydrochloric Acid SCHEMBL4858332 0.91 ACHE (0.46) TDP1ACHE
SCHEMBL13987460 0.90 TDP1 (0.45) TDP1ACHECYP11B1CYP11B2TP53
Hydrochloric Acid SCHEMBL4856236 0.89 TDP1 (0.44) TDP1ACHECYP11B1CYP11B2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7462628-B2 Preventives/remedies for urinary disturbance TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-12-09 US disclosed
US-7462628-B2 Preventives/remedies for urinary disturbance TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-12-09 US disclosed