Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.77 |
| ▸ | HTT | P42858 | 2/20 | 0.77 |
| ▸ | THRB | P10828 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 6/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9646500 | 1.00 | MEN1 (0.77) | MEN1KMT2AHTTTHRBMAPT | |
| SCHEMBL8956073 | 1.00 | MEN1 (0.77) | MEN1KMT2AHTTTHRBMAPT | |
| SCHEMBL2527727 | 1.00 | MEN1 (0.77) | MEN1KMT2AHTTTHRBMAPT | |
| SCHEMBL314263 | 1.00 | MEN1 (0.77) | MEN1KMT2AHTTTHRBMAPT | |
| SCHEMBL23014943 | 1.00 | MEN1 (0.77) | MEN1KMT2AHTTTHRBMAPT | |
| SCHEMBL2221085 | 1.00 | MEN1 (0.77) | MEN1KMT2AHTTTHRBMAPT | |
| SCHEMBL23014835 | 1.00 | MEN1 (0.77) | MEN1KMT2AHTTTHRBMAPT | |
| SCHEMBL24304662 | 1.00 | MEN1 (0.77) | MEN1KMT2AHTTTHRBMAPT | |
| SCHEMBL16815923 | 1.00 | MEN1 (0.77) | MEN1KMT2AHTTTHRBMAPT | |
| SCHEMBL427999 | 1.00 | MEN1 (0.77) | MEN1KMT2AHTTTHRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9303051-B2 | Phosphonate ester derivatives and methods of synthesis thereof | CHIMERIX INC. (US) | 2016-04-05 | — | — | US | disclosed |
| US-20150329575-A1 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF | EMERGENT BIODEFENSE OPERATIONS LANSING LLC | 2015-11-19 | — | — | US | disclosed |
| US-20140046085-A1 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof | CHIMERIX, INC. (US) | 2014-02-13 | — | — | US | disclosed |
| US-8569321-B2 | Phosphonate ester derivatives and methods of synthesis thereof | CHIMERIX, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-20120058976-A1 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof | CHIMERIX, INC. (US) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058976-A1 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof | PHOSPHO1, PIK3CA, PNP | MEN1 1891/4885KMT2A 2791/4885HTT 4129/4885 |
| US-20140046085-A1 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof | PHOSPHO1, PIK3CA, PNP | MEN1 1891/4885KMT2A 2791/4885HTT 4129/4885 |
| US-20150329575-A1 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF | PHOSPHO1, PIK3CA, PNP | MEN1 1891/4885KMT2A 2791/4885HTT 4129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.