Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.70 |
| ▸ | MAPT | P10636 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | GAA | P10253 | 3/20 | 0.63 |
| ▸ | CACNA2D1 | P54289 | 10/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | RAD52 | P43351 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8359660 | 0.83 | TSHR (1.00) | KDM4ETSHRALOX15L3MBTL1MEN1 | |
| SCHEMBL8361374 | 0.83 | KDM4E (0.71) | KDM4ETSHRALOX15L3MBTL1MEN1 | |
| SCHEMBL5008011 | 0.83 | KDM4E (0.71) | KDM4ETSHRALOX15L3MBTL1MEN1 | |
| SCHEMBL8359653 | 0.83 | KDM4E (0.71) | KDM4ETSHRALOX15L3MBTL1MEN1 | |
| SCHEMBL8359669 | 0.83 | KDM4E (0.71) | KDM4ETSHRALOX15L3MBTL1MEN1 | |
| SCHEMBL5008016 | 0.83 | MEN1 (1.00) | KDM4ETSHRALOX15L3MBTL1MEN1 | |
| SCHEMBL5000967 | 0.80 | KDM4E (0.67) | KDM4ETSHRALOX15L3MBTL1MEN1 | |
| SCHEMBL8359537 | 0.78 | KDM4E (1.00) | KDM4ETSHRALOX15L3MBTL1MEN1 | |
| SCHEMBL8361379 | 0.77 | KDM4E (0.62) | KDM4ETSHRALOX15L3MBTL1MEN1 | |
| SCHEMBL5008010 | 0.77 | CACNA2D1 (1.00) | CACNA2D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465730-B2 | Treatment of neuropathic pain with 6H-pyrrolo[3,4-d]pyridazine compounds | MERCK & CO. INC. (US) | 2008-12-16 | — | — | US | disclosed |