Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 6/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 1.00 |
| ▸ | GAA | P10253 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 5/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.72 |
| ▸ | RAD52 | P43351 | 1/20 | 0.72 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | CACNA2D1 | P54289 | 7/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5004686 | 0.84 | KDM4E (0.72) | KDM4EMAPTALDH1A1GAAMEN1 | |
| SCHEMBL8361380 | 0.84 | KDM4E (1.00) | KDM4EMAPTALDH1A1GAAMEN1 | |
| SCHEMBL13993249 | 0.78 | KDM4E (1.00) | KDM4EMAPTALDH1A1GAAMEN1 | |
| SCHEMBL5001008 | 0.77 | CACNA2D1 (0.64) | KDM4EMAPTALDH1A1GAAMEN1 | |
| SCHEMBL8359669 | 0.74 | KDM4E (0.71) | KDM4EMAPTALDH1A1GAAMEN1 | |
| SCHEMBL8359653 | 0.74 | KDM4E (0.71) | KDM4EMAPTALDH1A1GAAMEN1 | |
| SCHEMBL8359660 | 0.74 | TSHR (1.00) | KDM4EMAPTALDH1A1GAAMEN1 | |
| SCHEMBL5008011 | 0.74 | KDM4E (0.71) | KDM4EMAPTALDH1A1GAAMEN1 | |
| SCHEMBL8361374 | 0.74 | KDM4E (0.71) | KDM4EMAPTALDH1A1GAAMEN1 | |
| SCHEMBL5001196 | 0.74 | MEN1 (0.63) | KDM4EMAPTALDH1A1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10350217-B2 | Antifungal agents and uses thereof | UNIVERSITY OF MASSACHUSETTS (US) | 2019-07-16 | — | — | US | disclosed |
| US-20170224703-A1 | ANTIFUNGAL AGENTS AND USES THEREOF | UNIVERSITY OF MASSACHUSETTS | 2017-08-10 | — | — | US | disclosed |
| US-20170224703-A1 | ANTIFUNGAL AGENTS AND USES THEREOF | UNIVERSITY OF MASSACHUSETTS | 2017-08-10 | — | — | US | disclosed |
| US-9648880-B2 | Antifungal agents and uses thereof | UNIVERSITY OF MASSACHUSETTS (US) | 2017-05-16 | — | — | US | disclosed |
| US-9648880-B2 | Antifungal agents and uses thereof | UNIVERSITY OF MASSACHUSETTS (US) | 2017-05-16 | — | — | US | disclosed |
| US-20140142107-A1 | ANTIFUNGAL AGENTS AND USES THEREOF | UNIVERSITY OF MASSACHUSETTS (US) | 2014-05-22 | — | — | US | disclosed |
| US-20140142107-A1 | ANTIFUNGAL AGENTS AND USES THEREOF | UNIVERSITY OF MASSACHUSETTS (US) | 2014-05-22 | — | — | US | disclosed |
| WO-2014039515-A2 | ANTIFUNGAL AGENTS AND USES THEREOF | UNIVERSITY OF MASSACHUSETTS (US) | 2014-03-13 | — | — | WO | disclosed |
| US-7465730-B2 | Treatment of neuropathic pain with 6H-pyrrolo[3,4-d]pyridazine compounds | MERCK & CO. INC. (US) | 2008-12-16 | — | — | US | disclosed |
| US-7465730-B2 | Treatment of neuropathic pain with 6H-pyrrolo[3,4-d]pyridazine compounds | MERCK & CO. INC. (US) | 2008-12-16 | — | — | US | disclosed |
| WO-2004006836-A2 | TREATMENT OF NEUROPATHIC PAIN WITH 6H-PYRROLO[3,4-D]PYRIDAZINE COMPOUNDS | MERCK & CO., INC. (US) | 2004-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142107-A1 | ANTIFUNGAL AGENTS AND USES THEREOF | DPM1, ERG28, SUCLG1 | KDM4E 4235/4885MAPT 2415/4885ALDH1A1 1365/4885 |
| US-20170224703-A1 | ANTIFUNGAL AGENTS AND USES THEREOF | DPM1, ERG28, SUCLG1 | KDM4E 4235/4885MAPT 2415/4885ALDH1A1 1365/4885 |
| US-10350217-B2 | Antifungal agents and uses thereof | DPM1, ERG28, SUCLG1 | KDM4E 4235/4885MAPT 2415/4885ALDH1A1 1365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.