Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.44 |
| ▸ | CDK14 | O94921 | 10/20 | 0.44 |
| ▸ | CCNY | Q8ND76 | 8/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CCR8 | P51685 | 1/20 | 0.42 |
| ▸ | CASK | O14936 | 1/20 | 0.42 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2029686 | 0.94 | CDK14 (0.48) | LMNARAB9ACCNT1CDK9CDK5 | |
| SCHEMBL8262590 | 0.94 | MEN1 (0.45) | LMNARAB9ACDK14CCNYMEN1 | |
| SCHEMBL8261492 | 0.90 | CDK2 (0.49) | LMNARAB9ACCNT1CDK9CDK5 | |
| SCHEMBL8262596 | 0.90 | CDK14 (0.43) | LMNARAB9ACCNT1CDK9CDK5 | |
| SCHEMBL8263999 | 0.90 | CDK14 (0.52) | LMNARAB9ACDK14CCNYCNR1 | |
| SCHEMBL8264010 | 0.89 | GLA (0.45) | CDK14CCNYMEN1KMT2AALDH1A1 | |
| SCHEMBL8261500 | 0.88 | CDK14 (0.43) | LMNARAB9ACDK14CCNYMEN1 | |
| SCHEMBL8261512 | 0.88 | CDK14 (0.44) | LMNARAB9ACCNT1CDK9CDK5 | |
| SCHEMBL13993682 | 0.88 | HSP90AA1 (0.40) | LMNARAB9ACDK14CCNYCNR1 | |
| SCHEMBL8261501 | 0.87 | CDK14 (0.45) | CDK14CCNYCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080306069-A1 | Pyrazole Derivatives for the Inhibition of CDK'S and GSK'S | ASTEX THERAPEUTICS LIMITED (UK) | 2008-12-11 | — | — | US | disclosed |
| US-20080306069-A1 | Pyrazole Derivatives for the Inhibition of CDK'S and GSK'S | ASTEX THERAPEUTICS LIMITED (UK) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306069-A1 | Pyrazole Derivatives for the Inhibition of CDK'S and GSK'S | GSK3A, CDK11A, CDK1 | LMNA 367/4885RAB9A 886/4885CCNT1 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.