Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | CDK14 | O94921 | 6/20 | 0.38 |
| ▸ | CCNY | Q8ND76 | 6/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | SETD2 | Q9BYW2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8264003 | 0.91 | ALDH1A1 (0.41) | ALDH1A1CDK14CCNYEPHX2NPY5R | |
| SCHEMBL8264009 | 0.90 | NPY5R (0.42) | HSP90AA1HSP90AB1PDK1ALDH1A1CCR5 | |
| SCHEMBL8261500 | 0.88 | CDK14 (0.43) | HSP90AA1HSP90AB1PDK1ALDH1A1LMNA | |
| SCHEMBL13993680 | 0.88 | ALDH1A1 (0.39) | HSP90AA1HSP90AB1PDK1ALDH1A1LMNA | |
| SCHEMBL13993660 | 0.88 | LMNA (0.46) | ALDH1A1LMNACNR1CDK14CCNY | |
| SCHEMBL2029686 | 0.87 | CDK14 (0.48) | ALDH1A1LMNACNR1CDK14CCNY | |
| SCHEMBL8261492 | 0.87 | CDK2 (0.49) | LMNAMAPTCNR1CDK14CCNY | |
| SCHEMBL13993685 | 0.86 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1PDK1ALDH1A1CNR1 | |
| SCHEMBL13993675 | 0.85 | ALDH1A1 (0.41) | HSP90AA1HSP90AB1PDK1ALDH1A1CNR1 | |
| SCHEMBL13993647 | 0.85 | ALDH1A1 (0.42) | ALDH1A1CDK14CCNYEPHX2NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080306069-A1 | Pyrazole Derivatives for the Inhibition of CDK'S and GSK'S | ASTEX THERAPEUTICS LIMITED (UK) | 2008-12-11 | — | — | US | disclosed |
| US-20080306069-A1 | Pyrazole Derivatives for the Inhibition of CDK'S and GSK'S | ASTEX THERAPEUTICS LIMITED (UK) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306069-A1 | Pyrazole Derivatives for the Inhibition of CDK'S and GSK'S | GSK3A, CDK11A, CDK1 | HSP90AA1 1535/4885HSP90AB1 2087/4885PDK1 96/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.