Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 15/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 9/20 | 0.48 |
| ▸ | AR | P10275 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | G6PD | P11413 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12883425 | 0.80 | POLB (0.45) | TP53GAAKMT2AL3MBTL1 | |
| SCHEMBL2059694 | 0.78 | TDP1 (0.54) | ESR1ESR2ARTP53TDP1 | |
| SCHEMBL8350047 | 0.76 | TP53 (0.52) | ESR1ESR2ARTP53TDP1 | |
| SCHEMBL12403864 | 0.75 | RAPGEF4 (0.39) | IDO1GAAKMT2A | |
| SCHEMBL19220414 | 0.75 | MEN1 (0.41) | IDO1MEN1GAAKMT2A | |
| SCHEMBL6572164 | 0.75 | ESR1 (0.48) | ESR1ESR2ARTP53TDP1 | |
| SCHEMBL19194280 | 0.75 | CYP1A2 (0.32) | MEN1GAAG6PDKMT2AL3MBTL1 | |
| SCHEMBL12883522 | 0.75 | CYP1A2 (0.46) | TDP1MEN1GAAKMT2A | |
| SCHEMBL27612346 | 0.74 | TDP1 (0.50) | ESR1ESR2ARTP53TDP1 | |
| SCHEMBL27995684 | 0.74 | PDE10A (0.52) | ESR1ESR2ARTP53TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465726-B2 | Substituted pyrrolo[2.3-B]pyridines | OSI PHARMACEUTICALS, INC. (US) | 2008-12-16 | — | — | US | disclosed |
| US-7465726-B2 | Substituted pyrrolo[2.3-B]pyridines | OSI PHARMACEUTICALS, INC. (US) | 2008-12-16 | — | — | US | disclosed |