Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 6/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13994335 | 0.96 | MET (0.57) | METMAPTTP53HDAC1USP2 | |
| SCHEMBL13247395 | 0.91 | MET (0.71) | METMAPTTP53HDAC1 | |
| SCHEMBL13994523 | 0.91 | MET (0.57) | MET | |
| SCHEMBL13247393 | 0.87 | MET (0.68) | METHDAC1 | |
| SCHEMBL13994632 | 0.87 | MET (0.61) | METMAPT | |
| SCHEMBL13994592 | 0.87 | MET (0.61) | MET | |
| SCHEMBL13247403 | 0.85 | MET (0.73) | METMAPTTP53USP2PKM | |
| SCHEMBL13994272 | 0.84 | MET (0.62) | METMAPTTP53KDM4E | |
| SCHEMBL13994271 | 0.83 | MET (0.62) | MET | |
| SCHEMBL13247334 | 0.83 | MET (0.67) | METTP53HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008145243-A1 | PYRIDAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-12-04 | — | — | WO | disclosed |