Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.42 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1047098 | 1.00 | ALDH1A1 (0.58) | ALDH1A1LMNAMAPTKMT2ATHRB | |
| SCHEMBL1047097 | 1.00 | ALDH1A1 (0.58) | ALDH1A1LMNAMAPTKMT2ATHRB | |
| SCHEMBL4812720 | 0.85 | ALDH1A1 (0.64) | ALDH1A1LMNAMAPTKMT2ATHRB | |
| SCHEMBL10126813 | 0.84 | ALDH1A1 (0.49) | ALDH1A1LMNAMAPTKMT2AGAA | |
| SCHEMBL1046567 | 0.83 | HTT (0.67) | ALDH1A1LMNAMAPTKMT2ATHRB | |
| SCHEMBL1046568 | 0.83 | HTT (0.67) | ALDH1A1LMNAMAPTKMT2ATHRB | |
| SCHEMBL6211272 | 0.81 | ALDH1A1 (0.61) | ALDH1A1LMNAMAPTKMT2ATHRB | |
| SCHEMBL7805673 | 0.81 | ALDH1A1 (0.61) | ALDH1A1LMNAMAPTKMT2ATHRB | |
| SCHEMBL7812644 | 0.81 | ALDH1A1 (0.61) | ALDH1A1LMNAMAPTKMT2ATHRB | |
| SCHEMBL7812642 | 0.81 | ALDH1A1 (0.61) | ALDH1A1LMNAMAPTKMT2ATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086540-B8 | TRIAZOLOPYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2011-03-02 | — | — | EP | disclosed |
| EP-2086540-A1 | TRIAZOLOPYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | Galapagos N.V. (BE) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008065198-A1 | TRIAZOLOPYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS N.V. (BE) | 2008-06-05 | — | — | WO | disclosed |