Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | NMUR2 | Q9GZQ4 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL734480 | 0.83 | KDM4E (0.65) | KDM4ETSHRSMN1; SMN2ALDH1A1HTR1A | |
| SCHEMBL12357051 | 0.83 | KDM4E (0.65) | KDM4ETSHRSMN1; SMN2ALDH1A1HTR1A | |
| SCHEMBL21985069 | 0.83 | — | — | |
| SCHEMBL13754782 | 0.82 | KDM4E (0.71) | KDM4ESMN1; SMN2ALDH1A1HTR1ATHPO | |
| SCHEMBL22841411 | 0.82 | KDM4E (0.71) | KDM4ESMN1; SMN2ALDH1A1HTR1ATHPO | |
| SCHEMBL19080649 | 0.78 | KDM4E (0.65) | KDM4ESMN1; SMN2ALDH1A1HTR1ATHPO | |
| SCHEMBL18756076 | 0.78 | KDM4E (0.65) | KDM4ESMN1; SMN2ALDH1A1HTR1ATHPO | |
| SCHEMBL84097 | 0.78 | TSHR (0.42) | TSHRALDH1A1TDP1 | |
| SCHEMBL108664 | 0.77 | TSHR (0.53) | TSHRALDH1A1TDP1 | |
| SCHEMBL9150878 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008150837-A1 | METHODS OF TREATMENT | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-11 | — | — | WO | disclosed |