Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 20/20 | 1.00 |
| ▸ | RAMP1 | O60894 | 5/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4570723 | 1.00 | CALCRL (1.00) | CALCRLRAMP1 | |
| SCHEMBL14173372 | 0.92 | CALCRL (0.84) | CALCRLRAMP1 | |
| SCHEMBL13253208 | 0.91 | CALCRL (0.83) | CALCRLRAMP1 | |
| SCHEMBL14173354 | 0.86 | CALCRL (0.76) | CALCRLRAMP1 | |
| SCHEMBL12219713 | 0.83 | CALCRL (0.86) | CALCRLRAMP1 | |
| SCHEMBL14173355 | 0.83 | CALCRL (0.70) | CALCRLRAMP1 | |
| SCHEMBL14173359 | 0.82 | CALCRL (0.75) | CALCRLRAMP1 | |
| SCHEMBL15284002 | 0.81 | CALCRL (0.68) | CALCRLRAMP1 | |
| SCHEMBL14173356 | 0.81 | CALCRL (0.75) | CALCRLRAMP1 | |
| SCHEMBL2766644 | 0.79 | CALCRL (0.74) | CALCRLRAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993588-B2 | Carboxamide heterocyclic CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2015-03-31 | — | — | US | disclosed |
| WO-2008153849-A1 | CARBOXAMIDE HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2008-12-18 | — | — | WO | disclosed |