Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 20/20 | 0.83 |
| ▸ | RAMP1 | O60894 | 5/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13997598 | 0.91 | CALCRL (1.00) | CALCRLRAMP1 | |
| SCHEMBL4570723 | 0.91 | CALCRL (1.00) | CALCRLRAMP1 | |
| SCHEMBL14173372 | 0.82 | CALCRL (0.84) | CALCRLRAMP1 | |
| SCHEMBL14173354 | 0.77 | CALCRL (0.76) | CALCRLRAMP1 | |
| SCHEMBL2527814 | 0.76 | CALCRL (0.59) | CALCRLRAMP1 | |
| SCHEMBL14173355 | 0.74 | CALCRL (0.70) | CALCRLRAMP1 | |
| SCHEMBL12219713 | 0.74 | CALCRL (0.86) | CALCRLRAMP1 | |
| SCHEMBL12219333 | 0.73 | CALCRL (0.56) | CALCRLRAMP1 | |
| SCHEMBL14173359 | 0.72 | CALCRL (0.75) | CALCRLRAMP1 | |
| SCHEMBL12219794 | 0.72 | CALCRL (0.60) | CALCRLRAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993588-B2 | Carboxamide heterocyclic CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2015-03-31 | — | — | US | disclosed |
| US-20100179166-A1 | CARBOXAMIDE HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179166-A1 | CARBOXAMIDE HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS | BDKRB1, BDKRB2, CCKBR | CALCRL 6/4885RAMP1 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.