Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 14/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 4/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13998541 | 0.90 | GSK3B (0.71) | GSK3BMAPK1HTTCHEK1CDK2 | |
| SCHEMBL14492492 | 0.89 | GSK3B (0.59) | GSK3BMAPK1HTTCDK2CCNE1 | |
| SCHEMBL13998548 | 0.88 | GSK3B (0.73) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL13998536 | 0.84 | GSK3B (0.54) | GSK3BCDK2 | |
| SCHEMBL13998623 | 0.83 | GSK3B (0.55) | GSK3BCDK2 | |
| SCHEMBL13998473 | 0.82 | GSK3B (0.52) | GSK3BCDK2CCNE1 | |
| SCHEMBL12952848 | 0.82 | GSK3B (1.00) | GSK3BCDK2CCNE1 | |
| SCHEMBL12953591 | 0.81 | GSK3B (0.98) | GSK3BCDK2CCNE1 | |
| SCHEMBL14043181 | 0.81 | GSK3B (0.60) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL14547158 | 0.78 | GSK3B (0.49) | GSK3BCDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470695-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2008-12-30 | — | — | US | disclosed |
| US-7470695-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2008-12-30 | — | — | US | disclosed |
| EP-1534709-B1 | PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2007044401-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |
| US-7196092-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196092-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |