Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 14/20 | 0.71 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.44 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13998535 | 0.90 | GSK3B (0.70) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL13998492 | 0.89 | GSK3B (0.64) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL13998548 | 0.88 | GSK3B (0.73) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL14012147 | 0.88 | GSK3B (0.55) | GSK3BCHEK1MAPK1HTT | |
| SCHEMBL14492492 | 0.87 | GSK3B (0.59) | GSK3BCDK2MAPK1HTTCCNE1 | |
| SCHEMBL13893782 | 0.83 | GSK3B (0.57) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL12952914 | 0.83 | GSK3B (1.00) | GSK3BCDK2CCNE1 | |
| SCHEMBL11936841 | 0.80 | GSK3B (0.63) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL13885182 | 0.79 | GSK3B (0.58) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL13998511 | 0.78 | GSK3B (0.67) | GSK3BCHEK1CDK2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470695-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2008-12-30 | — | — | US | disclosed |
| US-7470695-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2008-12-30 | — | — | US | disclosed |
| EP-1534709-B1 | PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2007044401-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |
| US-7196092-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196092-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |