Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1605672 | 1.00 | ALDH1A1 (0.35) | ALDH1A1CTSKCNR2CNR1JAK2 | |
| SCHEMBL1605674 | 1.00 | ALDH1A1 (0.35) | ALDH1A1CTSKCNR2CNR1JAK2 | |
| SCHEMBL1606475 | 0.93 | ALDH1A1 (0.34) | ALDH1A1CTSKCNR2CNR1JAK2 | |
| SCHEMBL1606477 | 0.93 | ALDH1A1 (0.34) | ALDH1A1CTSKCNR2CNR1JAK2 | |
| SCHEMBL1605843 | 0.93 | ALDH1A1 (0.34) | ALDH1A1CTSKCNR2CNR1JAK2 | |
| SCHEMBL1605847 | 0.93 | ALDH1A1 (0.34) | ALDH1A1CTSKCNR2CNR1JAK2 | |
| SCHEMBL1605844 | 0.93 | ALDH1A1 (0.34) | ALDH1A1CTSKCNR2CNR1JAK2 | |
| SCHEMBL13998501 | 0.93 | ALDH1A1 (0.34) | ALDH1A1CTSKCNR2CNR1JAK2 | |
| SCHEMBL13998475 | 0.93 | ALDH1A1 (0.34) | ALDH1A1CTSKCNR2CNR1JAK2 | |
| SCHEMBL1605100 | 0.88 | EPHX1 (0.35) | ALDH1A1CNR2JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753736-B1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | AMGEN INC (US) | 2008-12-17 | — | — | EP | disclosed |