Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1606529 | 1.00 | HSD11B1 (0.39) | HSD11B1P2RX7JAK2JAK1TAS1R3 | |
| SCHEMBL1606525 | 1.00 | HSD11B1 (0.39) | HSD11B1P2RX7JAK2JAK1TAS1R3 | |
| SCHEMBL1604943 | 1.00 | HSD11B1 (0.39) | HSD11B1P2RX7JAK2JAK1TAS1R3 | |
| SCHEMBL14531577 | 1.00 | HSD11B1 (0.39) | HSD11B1P2RX7JAK2JAK1TAS1R3 | |
| SCHEMBL1604940 | 1.00 | HSD11B1 (0.39) | HSD11B1P2RX7JAK2JAK1TAS1R3 | |
| SCHEMBL1604697 | 1.00 | HSD11B1 (0.39) | HSD11B1P2RX7JAK2JAK1TAS1R3 | |
| SCHEMBL5016455 | 1.00 | HSD11B1 (0.39) | HSD11B1P2RX7JAK2JAK1TAS1R3 | |
| SCHEMBL1604698 | 1.00 | HSD11B1 (0.39) | HSD11B1P2RX7JAK2JAK1TAS1R3 | |
| SCHEMBL1560406 | 1.00 | HSD11B1 (0.39) | HSD11B1P2RX7JAK2JAK1TAS1R3 | |
| SCHEMBL1604699 | 1.00 | HSD11B1 (0.39) | HSD11B1P2RX7JAK2JAK1TAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753736-B1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | AMGEN INC (US) | 2008-12-17 | — | — | EP | disclosed |