Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | C1R | P00736 | 1/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.34 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.34 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.34 |
| ▸ | EPHB3 | P54753 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.34 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1606206 | 0.90 | NISCH (0.38) | NISCHALDH1A1L3MBTL1HTTNPC1 | |
| SCHEMBL1605216 | 0.89 | NPC1 (0.39) | NISCHALDH1A1L3MBTL1HTTNPC1 | |
| SCHEMBL1605723 | 0.86 | NISCH (0.36) | NISCHALDH1A1L3MBTL1HTTNPC1 | |
| SCHEMBL1605191 | 0.82 | MAPK10 (0.36) | NISCHALDH1A1L3MBTL1HTTNPC1 | |
| SCHEMBL1605230 | 0.82 | MAPK10 (0.36) | NISCHALDH1A1L3MBTL1HTTNPC1 | |
| SCHEMBL1605187 | 0.82 | MAPK10 (0.36) | NISCHALDH1A1L3MBTL1HTTNPC1 | |
| SCHEMBL1604314 | 0.74 | KMT2A (0.37) | ALDH1A1L3MBTL1HTTNPC1RAB9A | |
| SCHEMBL1604395 | 0.74 | LMNA (0.47) | ALDH1A1L3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1604762 | 0.74 | NISCH (0.42) | NISCHALDH1A1L3MBTL1HTTNPC1 | |
| SCHEMBL1604478 | 0.73 | LMNA (0.46) | ALDH1A1SMN1; SMN2MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753736-B1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | AMGEN INC (US) | 2008-12-17 | — | — | EP | disclosed |