SCHEMBL13999926

SCHEMBL13999926

CCCCc1nc2c(N)nc3ccccc3c2n1CCOCCNS(=O)(=O)c1ccc(C(C)(F)F)cc1

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 20/20 0.53
TLR8 Q9NR97 13/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13999871 0.95 TLR7 (0.54) TLR7TLR8
SCHEMBL13999856 0.91 TLR7 (0.60) TLR7TLR8
SCHEMBL13999872 0.91 TLR7 (0.53) TLR7TLR8
SCHEMBL13999877 0.90 TLR7 (0.59) TLR7TLR8
SCHEMBL13999866 0.90 TLR7 (0.57) TLR7TLR8
SCHEMBL13999864 0.89 TLR7 (0.61) TLR7TLR8
SCHEMBL13999861 0.87 TLR7 (0.54) TLR7TLR8
SCHEMBL13999870 0.87 TLR7 (0.58) TLR7TLR8
SCHEMBL13721829 0.86 TLR7 (0.62) TLR7TLR8
SCHEMBL13721619 0.86 TLR7 (0.59) TLR7TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080306252-A1 SULFONAMIDO ETHER SUBSTITUTED IMIDAZOQUINOLINES COLEY PHARMACEUTICAL GROUP, INC. (US) 2008-12-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080306252-A1 SULFONAMIDO ETHER SUBSTITUTED IMIDAZOQUINOLINES IFNG, IRF3, IL2 TLR7 24/4885TLR8 50/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.