Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.59 |
| ▸ | PRKAB2 | O43741 | 15/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 15/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 15/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 15/20 | 0.47 |
| ▸ | PRKAG3 | Q9UGI9 | 15/20 | 0.47 |
| ▸ | PRKAG2 | Q9UGJ0 | 15/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 15/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13999486 | 0.86 | PRKAG1 (0.47) | NR1H4PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL14215772 | 0.85 | NR1H4 (0.59) | NR1H4NR1I2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL13999489 | 0.85 | NR1H4 (0.60) | NR1H4NR1I2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL13999491 | 0.84 | NR1H4 (0.42) | NR1H4NR1I2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL14215895 | 0.84 | NR1H4 (0.46) | NR1H4NR1I2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL13999479 | 0.84 | NR1H4 (0.59) | NR1H4NR1I2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL14215811 | 0.82 | NR1H4 (0.59) | NR1H4NR1I2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL13999592 | 0.82 | NR1H4 (0.59) | NR1H4NR1I2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL14215784 | 0.81 | NR1H4 (0.46) | NR1H4NR1I2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL13999579 | 0.81 | NR1H4 (0.46) | NR1H4NR1I2CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008157270-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |