Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCG | P01275 | 2/20 | 0.52 |
| ▸ | KHK | P50053 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.43 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.43 |
| ▸ | GCGR | P47871 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | ACP1 | P24666 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14000452 | 0.93 | GCG (0.50) | GCGKHKRAB9AMAPTHDAC4 | |
| Tert-Butyl Formate SCHEMBL27808400 | 0.89 | GCG (0.46) | GCGKHKRAB9AMAPTHDAC4 | |
| SCHEMBL3723766 | 0.79 | HDAC4 (0.54) | GCGHDAC4HDAC6PARP1KMT2A | |
| SCHEMBL3668247 | 0.78 | HRH3 (0.44) | PARP1PTK2 | |
| SCHEMBL3730320 | 0.75 | HDAC4 (0.55) | GCGHDAC4HDAC6PARP1 | |
| SCHEMBL4946424 | 0.75 | HDAC4 (0.55) | GCGHDAC4HDAC6PARP1 | |
| SCHEMBL27786338 | 0.74 | GCG (0.44) | GCGPARP1GCGRNPC1HPGDS | |
| SCHEMBL594567 | 0.74 | NPC1 (0.62) | KHKRAB9AHDAC4HDAC6SMYD3 | |
| SCHEMBL3667714 | 0.74 | SLC6A4 (0.45) | — | |
| SCHEMBL3666843 | 0.74 | SLC6A4 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147945-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2008-12-04 | — | — | WO | disclosed |