Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 12/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 12/20 | 0.49 |
| ▸ | SDHB | P21912 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3565445 | 0.86 | RAD51 (0.43) | PTGS1PTGS2SDHB | |
| SCHEMBL27627986 | 0.85 | PTGS2 (0.48) | PTGS1PTGS2 | |
| SCHEMBL3172171 | 0.75 | PTGS2 (0.47) | PTGS1PTGS2 | |
| SCHEMBL941919 | 0.74 | PDE4A (0.37) | — | |
| SCHEMBL13450400 | 0.74 | PTGS2 (0.52) | PTGS1PTGS2SDHB | |
| SCHEMBL13451114 | 0.72 | PTGS2 (0.48) | PTGS1PTGS2SDHB | |
| SCHEMBL3152021 | 0.72 | PTGS2 (0.48) | PTGS1PTGS2SDHB | |
| SCHEMBL30849314 | 0.71 | PTGS2 (0.51) | PTGS1PTGS2 | |
| SCHEMBL11700896 | 0.70 | CXCR2 (0.49) | PTGS1PTGS2 | |
| SCHEMBL3166548 | 0.70 | PTGS2 (0.43) | PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7446117-B2 | Cox-2 inhibiting pyridine derivatives | GLAXO GROUP LIMITED (GB) | 2008-11-04 | — | — | US | disclosed |
| CN-1681788-A | COX-2 inhibiting pyridine derivatives | GLAXO GROUP LTD (GB) | 2005-10-12 | — | — | CN | disclosed |