Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 16/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.56 |
| ▸ | PIM1 | P11309 | 3/20 | 0.56 |
| ▸ | AKT2 | P31751 | 3/20 | 0.56 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.56 |
| ▸ | GSK3A | P49840 | 3/20 | 0.56 |
| ▸ | GSK3B | P49841 | 3/20 | 0.56 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.56 |
| ▸ | CDC7 | O00311 | 2/20 | 0.56 |
| ▸ | PLK4 | O00444 | 2/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.56 |
| ▸ | AURKA | O14965 | 2/20 | 0.56 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.56 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.56 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.56 |
| ▸ | PAK4 | O96013 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14004833 | 0.85 | AKT1 (0.57) | AKT1RPS6KB1PDPK1PIM1AKT2 | |
| SCHEMBL14004866 | 0.85 | AKT1 (0.57) | AKT1RPS6KB1PDPK1PIM1AKT2 | |
| SCHEMBL14005208 | 0.84 | AKT1 (0.46) | AKT1RPS6KB1PIM1AKT2CSNK1D | |
| SCHEMBL14005271 | 0.83 | AKT1 (0.48) | AKT1RPS6KB1PDPK1PIM1AKT2 | |
| SCHEMBL14004831 | 0.83 | AKT1 (0.48) | AKT1RPS6KB1PDPK1PIM1AKT2 | |
| SCHEMBL14005282 | 0.83 | AKT1 (0.47) | AKT1RPS6KB1PIM1AKT2CSNK1D | |
| SCHEMBL14004834 | 0.83 | AKT1 (0.59) | AKT1RPS6KB1PIM1AKT2CSNK1D | |
| SCHEMBL14004889 | 0.83 | AKT1 (0.59) | AKT1RPS6KB1PIM1AKT2CSNK1D | |
| SCHEMBL14004891 | 0.81 | AKT1 (0.56) | AKT1RPS6KB1PDPK1PIM1AKT2 | |
| SCHEMBL14005202 | 0.80 | AKT1 (0.61) | AKT1RPS6KB1PDPK1PIM1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | WYETH (US) | 2008-11-27 | — | — | US | disclosed |
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | WYETH (US) | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | PDPK1, PDK2, PDK3 | AKT1 157/4885RPS6KB1 250/4885PDPK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.