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PDK3

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial · Q15120 · PDK3 on Sugi Atlas →

39,320 patent compounds predicted against PDK3, 21,120 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL618106 SCHEMBL618106 0.70 15/20
SCHEMBL568924 SCHEMBL568924 0.45 11/20
SCHEMBL568925 SCHEMBL568925 0.45 11/20
SCHEMBL569205 SCHEMBL569205 0.45 11/20
SCHEMBL331761 SCHEMBL331761 0.52 7/20
SCHEMBL689543 SCHEMBL689543 0.52 7/20
SCHEMBL689544 SCHEMBL689544 0.52 7/20
SCHEMBL690815 SCHEMBL690815 0.52 7/20
SCHEMBL291862 SCHEMBL291862 0.54 6/20
SCHEMBL6969 SCHEMBL6969 0.41 6/20
SCHEMBL291691 SCHEMBL291691 0.52 5/20
SCHEMBL443096 SCHEMBL443096 0.45 5/20
SCHEMBL13664 SCHEMBL13664 0.35 5/20
SCHEMBL451495 SCHEMBL451495 0.55 4/20
SCHEMBL380901 SCHEMBL380901 0.53 4/20
SCHEMBL202154 SCHEMBL202154 0.46 4/20
Norelgestromin Norelgestromin (SCHEMBL118611) 0.73 3/20
Norgestimate Norgestimate (SCHEMBL38317) 0.55 3/20
Norgestimate Norgestimate (SCHEMBL38318) 0.55 3/20
Norgestimate Norgestimate (SCHEMBL633395) 0.55 3/20

Clinical trials — most relevant to PDK3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Glutamate for Metabolic Intervention in Coronary Surgery PHASE3COMPLETED
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
Efficacy and Safety of the Treatment of Pyruvate Dehydrogenase Deficiency Patients With Glycerol Phenylbutyrate (RAVICTI) PHASE2RECRUITING
Magnetic Resonance Imaging (MRI) With Hyperpolarized Pyruvate (13C) as Diagnostic Tool in Advanced Prostate Cancer PHASE2SUSPENDED
Thiamine as an Adjunctive Therapy in Cardiac Surgery PHASE2COMPLETED
Bempedoic Acid Therapy for Polycystic Kidney Disease PHASE2NOT_YET_RECRUITING
Simultaneous Hyperpolarized [1-13C]Pyruvate and 18F-FDG PET/MRS in Cancer Patients PHASE2UNKNOWN
Hyperpolarized 13C Pyruvate MRI Scan in Predicting Tumor Aggressiveness in Patients With Renal Tumors PHASE2ACTIVE_NOT_RECRUITING
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder PHASE2WITHDRAWN
Metformin Plus/Minus Fasting Mimicking Diet to Target the Metabolic Vulnerabilities of LKB1-inactive Lung Adenocarcinoma PHASE2UNKNOWN
Prevention of Acute Myocardial Injury by Trimetazidine in Patients Hospitalized for COVID-19 PHASE2UNKNOWN
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers PHASE1COMPLETED
A Phase I, Open-Labeled, Single-Arm, Dose Escalation, Clinical and Pharmacology Study of Dichloroacetate (DCA) in Patients With Recurrent and/or Metastatic Solid Tumours PHASE1COMPLETED
High-Dose Vitamin C in G6PDA and Pyruvate Kinase Deficiency: A Safety Study PHASE1NOT_YET_RECRUITING
Dichloroacetate (DCA) for the Treatment of Pulmonary Arterial Hypertension PHASE1COMPLETED
Imaging of Traumatic Brain Injury Metabolism Using Hyperpolarized Carbon-13 Pyruvate EARLY_PHASE1ENROLLING_BY_INVITATION
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation nanCOMPLETED
Biologic Mechanisms for Pain Variation After Physical Activity in Osteoarthritis nanCOMPLETED
Mechanisms of the Effect of Physical Activity on the Adaptation to a High-Fat Diet nanCOMPLETED
Alternative Substrates in the Critically Ill Subject nanCOMPLETED
Acute Effect of Fructose on Lipid Metabolism and Gender Differences nanCOMPLETED
Natural History and Advanced Genetic Study of Pyruvate Dehydrogenase Complex Deficiencies nanRECRUITING
Metabolic Remodeling in Pulmonary Arterial Hypertension (PAH) nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Molecular Mechanisms of Exercise Benefits to Insulin Resistant People nanCOMPLETED
13C Pyruvate DNP MR Spectroscopy for Lymphoma Treatment Response Assessment nanUNKNOWN
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus nanCOMPLETED
Natural History Study of Pyruvate Dehydrogenase Deficiency nanUNKNOWN
Effect of Acute Fructose Load in Human nanCOMPLETED
McArdle Disease Treatment by Ketogenic Diet nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a PDK3 binder may also engage these)

ProteinNameSimilarity
Q9JK42 — 1.000 Q9JK42 →
O70571 — 0.999 O70571 →
Q1KMR4 — 0.998 Q1KMR4 →
Q922H2 — 0.998 Q922H2 →
Q64536 — 0.997 Q64536 →
P91622 — 0.997 P91622 →
Q2KJG8 — 0.996 Q2KJG8 →
Q9P6P9 — 0.995 Q9P6P9 →
Q02332 — 0.993 Q02332 →
O54937 — 0.993 O54937 →
Q63065 — 0.993 Q63065 →
O88345 — 0.993 O88345 →
BCKDK Branched-chain alpha-ketoacid dehydrogenase kinase 0.992 landscape →
PDK1 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial 0.992 landscape →
P40530 — 0.992 P40530 →
O02623 — 0.992 O02623 →
Q8BFP9 — 0.991 Q8BFP9 →
PDK4 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 0.991 landscape →
PDK2 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 0.990 landscape →
O55028 — 0.990 O55028 →
Q00972 — 0.989 Q00972 →
P27515 — 0.988 P27515 →
Q09116 — 0.987 Q09116 →
O44476 — 0.987 O44476 →
SEPTIN6 Septin-6 0.987 landscape →
B6JWC1 — 0.987 B6JWC1 →
Q7ZY18 — 0.987 Q7ZY18 →
Q9M2Q4 — 0.987 Q9M2Q4 →
P19483 — 0.987 P19483 →
Q9R1T4 — 0.987 Q9R1T4 →