Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 13/20 | 0.35 |
| ▸ | PRKACA | P17612 | 3/20 | 0.34 |
| ▸ | PRKACG | P22612 | 3/20 | 0.34 |
| ▸ | PRKACB | P22694 | 3/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | ROS1 | P08922 | 1/20 | 0.33 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14031015 | 0.83 | AKT1 (0.37) | AKT1PRKACAPRKACGPRKACBCDC7 | |
| SCHEMBL14005324 | 0.82 | CYP2D6 (0.37) | AKT1PRKACAROCK2RPS6KB1AKT2 | |
| SCHEMBL14004847 | 0.79 | AKT1 (0.42) | AKT1PRKACAPDPK1ROCK2RPS6KB1 | |
| SCHEMBL14004852 | 0.79 | AKT1 (0.42) | AKT1PRKACAPDPK1ROCK2RPS6KB1 | |
| SCHEMBL14005638 | 0.79 | AKT1 (0.42) | AKT1PRKACAPDPK1ROCK2RPS6KB1 | |
| SCHEMBL14005347 | 0.78 | AKT1 (0.42) | AKT1 | |
| SCHEMBL14005355 | 0.78 | AKT1 (0.43) | AKT1PRKACAROCK2RPS6KA5RPS6KB1 | |
| SCHEMBL14005149 | 0.78 | AKT1 (0.36) | AKT1PRKACAPRKACGPRKACBCDC7 | |
| SCHEMBL14005318 | 0.77 | AKT1 (0.47) | AKT1PRKACAPRKACGPRKACBCDC7 | |
| SCHEMBL14005428 | 0.76 | AKT1 (0.42) | AKT1PRKACAPRKACGPRKACBCDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | WYETH (US) | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | PDPK1, PDK2, PDK3 | AKT1 157/4885PRKACA 6/4885PRKACG 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.