Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 11/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | PRKCB | P05771 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | PRKCA | P17252 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14006694 | 0.79 | ADORA2A (0.43) | KDM4EALDH1A1FLT1KDRFLT3 | |
| SCHEMBL14006703 | 0.79 | HDAC6 (0.50) | EPHB4ABL1EGFRSRCKDR | |
| SCHEMBL30256773 | 0.78 | GRM5 (0.43) | EPHB4KDM4EALDH1A1ABL1EGFR | |
| SCHEMBL14006717 | 0.78 | MC4R (0.60) | EPHB4ABL1EGFRPRKCBINSR | |
| SCHEMBL14006700 | 0.76 | ALOX5AP (0.43) | TLR8KMOADORA2A | |
| SCHEMBL14382359 | 0.75 | MAOB (0.44) | MAOBKDM4EXDHTLR8ADORA2A | |
| SCHEMBL1419883 | 0.75 | NPC1 (0.53) | KDM4EALDH1A1XDHTLR8ADORA2A | |
| SCHEMBL15411397 | 0.74 | PTPN11 (0.42) | MAOBEPHB4KDM4EABL1EGFR | |
| SCHEMBL15743496 | 0.73 | GRM5 (0.40) | EPHB4ADORA2A | |
| SCHEMBL1420319 | 0.72 | KMO (0.54) | EPHB4ABL1EGFRPRKCBINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7452902-B2 | Imidazopyridines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-18 | — | — | US | disclosed |
| US-7452902-B2 | Imidazopyridines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-18 | — | — | US | disclosed |
| EP-1539756-B1 | IMIDAZOPYRIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2007-11-14 | — | — | EP | disclosed |