Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | CASR | P41180 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14007245 | 0.90 | EPHX2 (0.66) | EPHX2ALDH1A1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL14007252 | 0.87 | EPHX2 (0.56) | EPHX2ALDH1A1SMN1; SMN2CD274HPGD | |
| SCHEMBL14007236 | 0.84 | EPHX2 (0.72) | EPHX2ALDH1A1SMN1; SMN2HPGDCYP2C19 | |
| SCHEMBL14007247 | 0.82 | EPHX2 (0.70) | EPHX2ALDH1A1SMN1; SMN2HPGDCYP2C19 | |
| SCHEMBL14007235 | 0.81 | EPHX2 (0.82) | EPHX2SMN1; SMN2HPGDCYP2C19 | |
| SCHEMBL14007263 | 0.81 | EPHX2 (0.55) | EPHX2ALDH1A1SMN1; SMN2CD274HPGD | |
| SCHEMBL14034441 | 0.81 | EPHX2 (0.67) | EPHX2ALDH1A1SMN1; SMN2HPGDCYP2C19 | |
| SCHEMBL14007242 | 0.80 | EPHX2 (0.76) | EPHX2SMN1; SMN2HPGDCYP2C19 | |
| SCHEMBL14007241 | 0.79 | EPHX2 (0.65) | EPHX2ALDH1A1SMN1; SMN2HPGDCYP2C19 | |
| SCHEMBL14007258 | 0.79 | EPHX2 (1.00) | EPHX2SMN1; SMN2CYP2C19CASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080280904-A1 | N-Substituted Pyridinone or Pyrimidinone Compounds Useful as Soluble Epoxide Hydrolase Inhibitors | ELDRUP ANNE BETTINA | 2008-11-13 | — | — | US | disclosed |
| US-20080280904-A1 | N-Substituted Pyridinone or Pyrimidinone Compounds Useful as Soluble Epoxide Hydrolase Inhibitors | ELDRUP ANNE BETTINA | 2008-11-13 | — | — | US | disclosed |
| WO-2007044491-A1 | N-SUBSTITUTED PYRIDINONE OR PYRIMIDINONE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280904-A1 | N-Substituted Pyridinone or Pyrimidinone Compounds Useful as Soluble Epoxide Hydrolase Inhibitors | EPHX1, EPHX2, DOHH | EPHX2 2/4885ALDH1A1 292/4885SMN1; SMN2 3162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.