DOHH

Deoxyhypusine hydroxylase · Q9BU89 · DOHH on Sugi Atlas →

12,282 patent compounds predicted against DOHH, 7,730 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Dipyridyl (SCHEMBL5922)	1.00	1/20
Ciclopirox (SCHEMBL34424)	1.00	1/20
Deferoxamine (SCHEMBL34571)	1.00	1/20
Mimosine (SCHEMBL41924)	1.00	1/20
L-Mimosine (SCHEMBL41925)	1.00	1/20
Deferiprone (SCHEMBL94474)	1.00	1/20
Deferiprone (SCHEMBL692741)	0.96	1/20
Dipyridyl (SCHEMBL137577)	0.93	1/20
Dipyridyl (SCHEMBL143849)	0.93	1/20
Dipyridyl (SCHEMBL182275)	0.93	1/20
Dipyridyl (SCHEMBL183651)	0.93	1/20
Dipyridyl (SCHEMBL202129)	0.93	1/20
Dipyridyl (SCHEMBL230578)	0.93	1/20
Dipyridyl (SCHEMBL287597)	0.93	1/20
Dipyridyl (SCHEMBL310586)	0.93	1/20
Dipyridyl (SCHEMBL391569)	0.93	1/20
Dipyridyl (SCHEMBL497901)	0.93	1/20
Dipyridyl (SCHEMBL498031)	0.93	1/20
Dipyridyl (SCHEMBL498331)	0.93	1/20
Dipyridyl (SCHEMBL501755)	0.93	1/20

Clinical trials — most relevant to DOHH by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Tetrahydrobiopterin (BH4) on Leg Blood Flow and Exercise Capacity in Patients With Peripheral Artery Disease	PHASE4	WITHDRAWN
Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors on Sarcopenia in Hemodialysis Patients	PHASE4	NOT_YET_RECRUITING
HepciFer Study: Hepcidin Overexpression After Hepatectomy : Does Iron Supplementation Make Sense ?	PHASE3	COMPLETED
Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers	PHASE2	NOT_YET_RECRUITING
Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes	PHASE2	UNKNOWN
A Study for Assessing the Efficacy and Safety of BH4 in Radiation Enteritis	PHASE2	UNKNOWN
Does Heme Oxygenase-1 Induction Ameliorate Cardiac Injury After Myocardial Infarction?	PHASE1/PHASE2	COMPLETED
Nitrite Infusion Studies	PHASE1	COMPLETED
Uterine Artery Doppler Changes After Vaginal Administration of Isosorbide Mononitrate In Patients With URPL	EARLY_PHASE1	UNKNOWN
Prognostic Value of (DHODH) Expression in (HGSOC): A Comparative Study Between Neoadjuvant and Adjuvant Chemotherapy Settings	nan	NOT_YET_RECRUITING
Mutation Analysis of 17α-Hydroxylase	nan	UNKNOWN
Effects of Preoperative Oral Carbohydrate Loading on Maternal Thiol-disulfide Homeostasis	nan	COMPLETED
Replacement of Vitamin D in Patients With Active Tuberculosis	nan	COMPLETED
Genetics and Pain Severity in Sickle Cell Disease	nan	COMPLETED
Elucidating the Molecular and Biochemical Basis of the Human AhR-mutation Disease	nan	UNKNOWN
Remote Ischemic Postconditioning Increases HIF-1α Plasma Levels and Improves Cardiac Markers After Cardiac Surgery	nan	COMPLETED
Mitochondrial Function of Immune Cells in Sepsis	nan	COMPLETED
Identification of Acute Intermittent Porphyria Modifying Genes	nan	RECRUITING
Cohort of Patients With Rare Iron Overloads Excluding C282Y Homozygosity	nan	COMPLETED
BMPR2 Mutations and Iron Metabolism in Pulmonary Arterial Hypertension	nan	COMPLETED
Studies in Porphyria I: Characterization of Enzyme Defects	nan	UNKNOWN
Cytochrome P450 Epoxygenase Pathway Regulation of Macrophage Function	nan	COMPLETED
Pilot Trial Investigating Every Other Day Dosing of Oral Iron in Premature Infants (IQONic)	nan	RECRUITING
Hemochromatosis and Iron Overload Screening Study (HEIRS)	nan	COMPLETED
Genetic Determinants of Congenital Heart Disease Outcomes	nan	COMPLETED
GDF 15 in Sickle Cell Disease and Hereditary Spherocytosis	nan	UNKNOWN
Mechanistic Studies of Teriflunomide in RRMS	nan	COMPLETED
Genes Associated With Development of Pulmonary Arterial Hypertension in Patients With Congenital Shunt Lesions	nan	RECRUITING
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside	nan	UNKNOWN
Gene Expression, Metabolomic, Microbiome, and Calcium Metabolism in Response to Varied Vitamin D Dosages	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a DOHH binder may also engage these)

Protein	Name	Similarity
Q0VC53	—	1.000	Q0VC53 →
Q99LN9	—	0.998	Q99LN9 →
Q5ZIP3	—	0.997	Q5ZIP3 →
Q5PPJ4	—	0.992	Q5PPJ4 →
Q66KT3	—	0.991	Q66KT3 →
Q7ZUX6	—	0.983	Q7ZUX6 →
Q9V9U4	—	0.975	Q9V9U4 →
Q297S2	—	0.975	Q297S2 →
Q17949	—	0.971	Q17949 →
Q752Z8	—	0.966	Q752Z8 →
D9IFD5	—	0.963	D9IFD5 →
Q2QXB3	—	0.963	Q2QXB3 →
Q96WP5	—	0.961	Q96WP5 →
P0CN11	—	0.959	P0CN11 →
Q2QLW3	—	0.957	Q2QLW3 →
Q6CHJ7	—	0.957	Q6CHJ7 →
P0CN10	—	0.957	P0CN10 →
Q8BNU0	—	0.956	Q8BNU0 →
Q556G4	—	0.955	Q556G4 →
Q94JW0	—	0.955	Q94JW0 →
Q5RD03	—	0.955	Q5RD03 →
Q6FUV3	—	0.955	Q6FUV3 →
A2QXL3	—	0.955	A2QXL3 →
Q8R307	—	0.953	Q8R307 →
Q7S891	—	0.953	Q7S891 →
PC	Pyruvate carboxylase, mitochondrial	0.953	landscape →
Q4PHU4	—	0.953	Q4PHU4 →
O95396	—	0.953	O95396 →
MVD	Diphosphomevalonate decarboxylase	0.952	landscape →
Q4HZ35	—	0.952	Q4HZ35 →