Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 2/20 | 0.56 |
| ▸ | CDK8 | P49336 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 5/20 | 0.55 |
| ▸ | BRAF | P15056 | 7/20 | 0.52 |
| ▸ | RAF1 | P04049 | 6/20 | 0.52 |
| ▸ | RET | P07949 | 3/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.52 |
| ▸ | KIT | P10721 | 2/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.52 |
| ▸ | FLT1 | P17948 | 2/20 | 0.52 |
| ▸ | MAOA | P21397 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13300975 | 0.85 | KDR (0.76) | CCNCCDK8KDRBRAFRAF1 | |
| SCHEMBL22754641 | 0.83 | CCNC (0.54) | CCNCCDK8KDRBRAFRAF1 | |
| SCHEMBL10324287 | 0.82 | RAF1 (0.75) | CCNCCDK8KDRBRAFRAF1 | |
| SCHEMBL20118148 | 0.78 | PARP1 (0.52) | CCNCCDK8KDRBRAFRAF1 | |
| SCHEMBL171188 | 0.78 | RAF1 (0.61) | CCNCCDK8KDRBRAFRAF1 | |
| SCHEMBL10105571 | 0.76 | RAF1 (0.66) | CCNCCDK8KDRBRAFRAF1 | |
| SCHEMBL14550467 | 0.75 | RAF1 (0.66) | CCNCCDK8KDRBRAFRAF1 | |
| SCHEMBL14481178 | 0.75 | RAF1 (0.71) | CCNCCDK8KDRBRAFRAF1 | |
| SCHEMBL10105574 | 0.75 | RAF1 (0.64) | CCNCCDK8KDRBRAFRAF1 | |
| SCHEMBL15218621 | 0.74 | BRAF (0.50) | CCNCCDK8KDRBRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7452901-B2 | Anti-cancer phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2008-11-18 | — | — | US | disclosed |