Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.52 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.51 |
| ▸ | WDR5 | P61964 | 2/20 | 0.48 |
| ▸ | F2 | P00734 | 2/20 | 0.47 |
| ▸ | F10 | P00742 | 2/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14009173 | 0.81 | KLKB1 (0.57) | NPC1F10MEN1KMT2A | |
| SCHEMBL14008951 | 0.80 | NPC1 (0.43) | NPC1POLBWDR5F2F10 | |
| SCHEMBL14609402 | 0.78 | CYP11B1 (0.43) | POLBF10CYP11B1CYP11B2MEN1 | |
| SCHEMBL14009015 | 0.77 | MAPT (0.46) | NPC1F10MEN1KMT2A | |
| SCHEMBL14009187 | 0.77 | MEN1 (0.48) | TNIKF10MEN1KMT2A | |
| SCHEMBL14009158 | 0.77 | NPC1 (0.54) | NPC1F10MEN1KMT2A | |
| SCHEMBL14009284 | 0.76 | CA1 (0.50) | NPC1F2F10MEN1KMT2A | |
| SCHEMBL14009231 | 0.76 | MAPT (0.52) | NPC1F10MEN1KMT2AGAA | |
| SCHEMBL14008962 | 0.75 | BLM (0.46) | NPC1POLBF2F10TBXAS1 | |
| SCHEMBL14009239 | 0.75 | RAB9A (0.56) | NPC1POLBMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7446195-B2 | High affinity thiophene-based and furan-based kinase ligands | SCHERING CORPORATION (US) | 2008-11-04 | — | — | US | disclosed |
| US-7446195-B2 | High affinity thiophene-based and furan-based kinase ligands | SCHERING CORPORATION (US) | 2008-11-04 | — | — | US | disclosed |
| US-20070043045-A1 | Novel high affinity thiophene-based and furan-based kinase ligands | SCHERING CORPORATION | 2007-02-22 | — | — | US | disclosed |
| US-20070043045-A1 | Novel high affinity thiophene-based and furan-based kinase ligands | SCHERING CORPORATION | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043045-A1 | Novel high affinity thiophene-based and furan-based kinase ligands | CDKL2, CDK2, CDKL1 | NPC1 4547/4885POLB 1045/4885CYP19A1 1610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.